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Tbio
SST
Somatostatin

Protein Summary
Description
Somatostatin inhibits the release of somatotropin. The hormone somatostatin has active 14 aa and 28 aa forms that are produced by alternate cleavage of the single preproprotein encoded by this gene. Somatostatin is expressed throughout the body and inhibits the release of numerous secondary hormones by binding to high-affinity G-protein-coupled somatostatin receptors. This hormone is an important regulator of the endocrine system through its interactions with pituitary growth hormone, thyroid stimulating hormone, and most hormones of the gastrointestinal tract. Somatostatin also affects rates of neurotransmission in the central nervous system and proliferation of both normal and tumorigenic cells. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287641
  • ENSP00000287641
  • ENSG00000157005

Symbol
  • SMST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.77
disease
0.76
kinase perturbation
0.76
gene perturbation
0.73
chemical
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16152.31   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 491   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16152.31   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 491   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Gene expression (Transcription)
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene expression (Transcription)
Gene Ontology Terms (19)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
UniProtKB
Protein-Protein Interactions (443)
1 – 10 of 443
SSTR2
Tclin
Family: GPCR
Novelty: 0.00200092
Score: 0.997
Data Source: STRINGDB
SSTR4
Tclin
Family: GPCR
Novelty: 0.01528237
Score: 0.995
Data Source: STRINGDB
SSTR5
Tclin
Family: GPCR
Novelty: 0.00568309
Score: 0.995
Data Source: STRINGDB
SSTR1
Tclin
Family: GPCR
Novelty: 0.00588024
Score: 0.995
Data Source: STRINGDB
SSTR3
Tclin
Family: GPCR
Novelty: 0.00899073
Score: 0.995
Data Source: STRINGDB
NPY
Tbio
Novelty: 0.00012637
Score: 0.991
Data Source: STRINGDB
PPY
Tbio
Novelty: 0.00060933
Score: 0.99
Data Source: STRINGDB
GAL
Tbio
Novelty: 0.0005132
Score: 0.979
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.979
Data Source: STRINGDB
CORT
Tbio
Novelty: 0.00789975
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  16152.31

PubMed score by year
PubTator Score  1964.62

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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