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Tbio
AIFM1
Apoptosis-inducing factor 1, mitochondrial

Protein Summary
Description
Functions both as NADH oxidoreductase and as regulator of apoptosis. In response to apoptotic stimuli, it is released from the mitochondrion intermembrane space into the cytosol and to the nucleus, where it functions as a proapoptotic factor in a caspase-independent pathway. In contrast, functions as an antiapoptotic factor in normal mitochondria via its NADH oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces 'parthanatos' i.e. caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the transl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287295
  • ENSP00000287295
  • ENSG00000156709
  • ENST00000319908
  • ENSP00000315122
  • ENST00000346424
  • ENSP00000316320
  • ENST00000416073
  • ENSP00000402535
  • ENST00000535724
  • ENSP00000446113

Symbol
  • AIF
  • PDCD8
  • AIF
  • CMT2D
  • CMTX4
  • COWCK
  • DFNX5
  • NADMR
  • NAMSD
  • PDCD8
  • COXPD6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
interacting protein
1
hub protein
0.92
protein domain
0.85
disease
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.33   (req: < 5)
Gene RIFs: 110   (req: <= 3)
Antibodies: 782   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.33   (req: >= 5)
Gene RIFs: 110   (req: > 3)
Antibodies: 782   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
apoptosis inducing factor mitochondria associated 1
VGNC:14685
100615914
Macaque
apoptosis inducing factor mitochondria associated 1
702773
Mouse
MGI:1349419
26926
Rat
RGD:620817
83533
Dog
apoptosis inducing factor mitochondria associated 1
VGNC:37737
481048
Species
Name
OMA
EggNOG
Inparanoid
Chimp
apoptosis inducing factor mitochondria associated 1
Macaque
apoptosis inducing factor mitochondria associated 1
Mouse
Rat
Dog
apoptosis inducing factor mitochondria associated 1
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (28)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (158)
1 – 10 of 158
AMZ1
Tdark
Family: Enzyme
Novelty: 0.246305
p_int: 0.999994686
p_ni: 0.000005314
Score: 0.185
Data Source: BioPlex,STRINGDB
CHCHD4
Tbio
Novelty: 0.01204944
p_int: 0.999738617
p_ni: 0.000261383
Score: 0.523
Data Source: BioPlex,STRINGDB
PTPN12
Tchem
Family: Enzyme
Novelty: 0.01333491
p_int: 0.999265934
p_ni: 0.000734066
Score: 0.158
Data Source: BioPlex,STRINGDB
APOOL
Tbio
Novelty: 0.08233023
p_int: 0.999239098
p_ni: 0.000760902
Score: 0.374
Data Source: BioPlex,STRINGDB
SLC25A23
Tbio
Family: Transporter
Novelty: 0.10446757
p_int: 0.997173147
p_ni: 0.002800276
p_wrong: 0.000026578
Score: 0.177
Data Source: BioPlex,STRINGDB
C17orf75
Tbio
Novelty: 0.08706784
p_int: 0.993268655
p_ni: 0.006731345
Score: 0.362
Data Source: BioPlex,STRINGDB
THAP4
Tbio
Family: TF
Novelty: 0.19820029
p_int: 0.992771757
p_ni: 0.007228243
Score: 0.549
Data Source: BioPlex,STRINGDB
SLC20A2
Tbio
Family: Transporter
Novelty: 0.00387767
p_int: 0.978138218
p_ni: 0.006718942
p_wrong: 0.015142839
Score: 0.267
Data Source: BioPlex,STRINGDB
SGPL1
Tchem
Family: Enzyme
Novelty: 0.00272574
p_int: 0.970765686
p_ni: 0.029234314
Score: 0.236
Data Source: BioPlex,STRINGDB
ACAD10
Tbio
Family: Enzyme
Novelty: 0.09858243
p_int: 0.962233384
p_ni: 0.037766616
Score: 0.244
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  100.33

PubMed score by year
PubTator Score  176.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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