You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CD109
CD109 antigen

Protein Summary
Description
Modulates negatively TGFB1 signaling in keratinocytes. This gene encodes a glycosyl phosphatidylinositol (GPI)-linked glycoprotein that localizes to the surface of platelets, activated T-cells, and endothelial cells. The protein binds to and negatively regulates signalling by transforming growth factor beta (TGF-beta). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287097
  • ENSP00000287097
  • ENSG00000156535
  • ENST00000422508
  • ENSP00000404475
  • ENST00000437994
  • ENSP00000388062

Symbol
  • CPAMD7
  • p180
  • r150
  • CPAMD7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
virus perturbation
0.85
kinase perturbation
0.81
PubMedID
0.79
histone modification site profile
0.78


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.6   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 337   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 99.6   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 337   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
4
96.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
96.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD109 molecule
VGNC:2656
462825
Macaque
CD109 molecule
716136
Mouse
MGI:2445221
235505
Rat
RGD:1311287
363104
Dog
CD109 molecule
VGNC:38929
474970
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD109 molecule
Macaque
CD109 molecule
Mouse
Rat
Dog
CD109 molecule
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q6YHK3-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Metabolism of proteins
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Name
Explore in Pharos
Explore in Source
Hemostasis
Metabolism of proteins
Platelet activation, signaling and aggregation
Platelet degranulation
Post-translational modification: synthesis of GPI-anchored proteins
Protein-Protein Interactions (117)
1 – 10 of 117
CAPN1
Tchem
Novelty: 0.00252811
p_int: 0.999999895
p_ni: 9.6e-8
p_wrong: 9e-9
Data Source: BioPlex
LGALS3
Tchem
Novelty: 0.00032754
p_int: 0.999980968
p_ni: 0.000019031
p_wrong: 1e-9
Score: 0.373
Data Source: BioPlex,STRINGDB
LGALS9
Tchem
Novelty: 0.00381766
p_int: 0.998612817
p_ni: 0.001387183
Score: 0.34
Data Source: BioPlex,STRINGDB
SCGB1D1
Tbio
Novelty: 0.04199997
p_int: 0.998255239
p_ni: 0.001744761
Data Source: BioPlex
CAPN2
Tchem
Novelty: 0.00431673
p_int: 0.99307205
p_ni: 0.006927929
p_wrong: 2.1e-8
Data Source: BioPlex
HYOU1
Tbio
Novelty: 0.00833649
p_int: 0.99042235
p_ni: 0.00957765
p_wrong: 1e-9
Data Source: BioPlex
UCN3
Tbio
Novelty: 0.00996251
p_int: 0.990337088
p_ni: 0.00966283
p_wrong: 8.1e-8
Data Source: BioPlex
CYP19A1
Tclin
Family: Enzyme
Novelty: 0.0003187
p_int: 0.987692325
p_ni: 0.012307675
p_wrong: 1e-9
Score: 0.173
Data Source: BioPlex,STRINGDB
TAZ
Tbio
Novelty: 0.00372301
p_int: 0.986713644
p_ni: 0.013286313
p_wrong: 4.3e-8
Data Source: BioPlex
PSCA
Tbio
Novelty: 0.00323778
p_int: 0.986438387
p_ni: 0.013561588
p_wrong: 2.5e-8
Score: 0.9
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  99.60

PubMed score by year
PubTator Score  58.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: