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Tbio
GDF6
Growth/differentiation factor 6

Protein Summary
Description
Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts thr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287020
  • ENSP00000287020
  • ENSG00000156466

Symbol
  • BMP13
  • GDF16
  • KFM
  • KFS
  • KFS1
  • KFSL
  • SGM1
  • BMP13
  • CDMP2
  • SYNS4
  • BMP-13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.81
microRNA
0.76
phenotype
0.75
protein domain
0.73
tissue sample
0.61


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.76   (req: < 5)
Gene RIFs: 16   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 126.76   (req: >= 5)
Gene RIFs: 16   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth differentiation factor 6
VGNC:12017
472823
Mouse
MGI:95689
242316
Rat
RGD:620104
252834
Dog
growth differentiation factor 6
VGNC:54113
100686579
Horse
growth differentiation factor 6
VGNC:18292
100059475
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth differentiation factor 6
Mouse
Rat
Dog
growth differentiation factor 6
Horse
growth differentiation factor 6
Pathways (12)
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
TGF-beta signaling pathway
KEGG
Hippo signaling pathway
KEGG
Cytokine-cytokine receptor interaction
Name
Explore in Pharos
Explore in Source
TGF-beta signaling pathway
Hippo signaling pathway
Cytokine-cytokine receptor interaction
Protein-Protein Interactions (50)
1 – 10 of 50
BMPR1B
Tchem
Family: Kinase
Novelty: 0.00698763
Score: 0.889
Data Source: STRINGDB
BMPR1A
Tchem
Family: Kinase
Novelty: 0.00343928
Score: 0.876
Data Source: STRINGDB
BMPR2
Tchem
Family: Kinase
Novelty: 0.00155912
Score: 0.874
Data Source: STRINGDB
NOG
Tbio
Novelty: 0.0010373
Score: 0.828
Data Source: STRINGDB
CHRD
Tbio
Novelty: 0.00347659
Score: 0.783
Data Source: STRINGDB
AMHR2
Tbio
Family: Kinase
Novelty: 0.00479939
Score: 0.714
Data Source: STRINGDB
ACVR2B
Tchem
Family: Kinase
Novelty: 0.00555742
Score: 0.69
Data Source: STRINGDB
CSMD3
Tbio
Novelty: 0.05973987
Score: 0.621
Data Source: STRINGDB
PAEP
Tbio
Novelty: 0.00125851
Score: 0.62
Data Source: STRINGDB
SMAD5
Tbio
Family: TF
Novelty: 0.00405952
Score: 0.585
Data Source: STRINGDB
Publication Statistics
PubMed Score  126.76

PubMed score by year
PubTator Score  44.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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