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Tbio
CXCL13
C-X-C motif chemokine 13

Protein Summary
Description
Chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. Does not induce calcium release in B-lymphocytes. Binds to BLR1/CXCR5. B lymphocyte chemoattractant, independently cloned and named Angie, is an antimicrobial peptide and CXC chemokine strongly expressed in the follicles of the spleen, lymph nodes, and Peyer's patches. It preferentially promotes the migration of B lymphocytes (compared to T cells and macrophages), apparently by stimulating calcium influx into, and chemotaxis of, cells expressing Burkitt's lymphoma receptor 1 (BLR-1). It may therefore function in the homing of B lymphocytes to follicles. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286758
  • ENSP00000286758
  • ENSG00000156234

Symbol
  • BCA1
  • BLC
  • SCYB13
  • BLC
  • BCA1
  • ANGIE
  • BCA-1
  • BLR1L
  • ANGIE2
  • SCYB13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.94
molecular function
0.9
biological term
0.87
gene perturbation
0.61
small molecule perturbation
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 878.67   (req: < 5)
Gene RIFs: 149   (req: <= 3)
Antibodies: 537   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 878.67   (req: >= 5)
Gene RIFs: 149   (req: > 3)
Antibodies: 537   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tonsillectomy risk measurement
1
1
0
1.1
28
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
tonsillectomy risk measurement
0
1.1
28
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 13
VGNC:8667
738275
Macaque
C-X-C motif chemokine ligand 13
574224
Mouse
MGI:1888499
55985
Rat
RGD:1564256
498335
Dog
C-X-C motif chemokine ligand 13
VGNC:39747
608156
Species
Name
OMA
EggNOG
Inparanoid
Chimp
C-X-C motif chemokine ligand 13
Macaque
C-X-C motif chemokine ligand 13
Mouse
Rat
Dog
C-X-C motif chemokine ligand 13
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
Chemokine receptors bind chemokines (R-HSA-380108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chemokine receptors bind chemokines
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Chemokine receptors bind chemokines
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (36)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Protein-Protein Interactions (335)
1 – 10 of 335
GNB3
Tbio
Novelty: 0.0037117
p_int: 0.768706683
p_ni: 0.209813816
p_wrong: 0.021479501
Score: 0.9
Data Source: BioPlex,STRINGDB
CXCR5
Tbio
Family: GPCR
Novelty: 0.00214886
Score: 0.995
Data Source: Reactome,STRINGDB
CCL19
Tbio
Novelty: 0.00169711
Score: 0.993
Data Source: STRINGDB
CCL21
Tbio
Novelty: 0.00130736
Score: 0.991
Data Source: STRINGDB
CXCL9
Tbio
Novelty: 0.00073213
Score: 0.983
Data Source: STRINGDB
CXCR3
Tchem
Family: GPCR
Novelty: 0.00100538
Score: 0.977
Data Source: STRINGDB
CCL4L1
Tbio
Novelty: 0.00164787
Score: 0.977
Data Source: STRINGDB
CXCL12
Tbio
Novelty: 0.00026817
Score: 0.976
Data Source: STRINGDB
CXCL10
Tchem
Novelty: 0.00040194
Score: 0.972
Data Source: STRINGDB
CCR7
Tbio
Family: GPCR
Novelty: 0.00084453
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  878.67

PubMed score by year
PubTator Score  345.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer