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Tchem
NAAA
N-acylethanolamine-hydrolyzing acid amidase

Protein Summary
Description
Degrades bioactive fatty acid amides to their corresponding acids, with the following preference: N-palmitoylethanolamine > N-myristoylethanolamine > N-lauroylethanolamine = N-stearoylethanolamine > N-arachidonoylethanolamine > N-oleoylethanolamine. Also exhibits weak hydrolytic activity against the ceramides N-lauroylsphingosine and N-palmitoylsphingosine. This gene encodes an N-acylethanolamine-hydrolyzing enzyme which is highly similar to acid ceramidase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286733
  • ENSP00000286733
  • ENSG00000138744
  • ENST00000507956
  • ENSP00000427641

Symbol
  • ASAHL
  • PLT
  • PLT
  • ASAHL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.8
interacting protein
0.7
cellular component
0.68
tissue sample
0.68
disease
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.19   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 284.19   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 49
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
N-acylethanolamine acid amidase
VGNC:2071
739402
Macaque
N-acylethanolamine acid amidase
700991
Mouse
MGI:1914361
67111
Rat
RGD:1307267
497009
Horse
N-acylethanolamine acid amidase
VGNC:20534
100057831
Species
Name
OMA
EggNOG
Inparanoid
Chimp
N-acylethanolamine acid amidase
Macaque
N-acylethanolamine acid amidase
Mouse
Rat
Horse
N-acylethanolamine acid amidase
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02083-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (3)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Neurotransmitter release cycle
Reactome
Transmission across Chemical Synapses
Name
Explore in Pharos
Explore in Source
Neuronal System
Neurotransmitter release cycle
Transmission across Chemical Synapses
Protein-Protein Interactions (74)
1 – 10 of 74
SIAE
Tbio
Family: Enzyme
Novelty: 0.01138067
p_int: 0.999669874
p_ni: 0.000330126
Score: 0.75
Data Source: BioPlex,STRINGDB
RLN1
Tbio
Novelty: 0.03992636
p_int: 0.99941834
p_ni: 0.000179682
p_wrong: 0.000401978
Data Source: BioPlex
MAN2B2
Tbio
Family: Enzyme
Novelty: 0.11499103
p_int: 0.998229583
p_ni: 0.001758804
p_wrong: 0.000011613
Score: 0.61
Data Source: BioPlex,STRINGDB
EDEM1
Tbio
Family: Enzyme
Novelty: 0.01157706
p_int: 0.99704788
p_ni: 0.002951447
p_wrong: 6.73e-7
Data Source: BioPlex
ARSB
Tbio
Family: Enzyme
Novelty: 0.01044355
p_int: 0.994824816
p_ni: 0.005006623
p_wrong: 0.000168561
Score: 0.271
Data Source: BioPlex,STRINGDB
NDST1
Tbio
Family: Enzyme
Novelty: 0.00955868
p_int: 0.993577179
p_ni: 0.005757433
p_wrong: 0.000665388
Score: 0.181
Data Source: BioPlex,STRINGDB
ARSK
Tbio
Family: Enzyme
Novelty: 0.11486213
p_int: 0.990752457
p_ni: 0.00924754
p_wrong: 3e-9
Data Source: BioPlex
OAF
Tbio
Novelty: 0.07130797
p_int: 0.987626863
p_ni: 0.012373137
Data Source: BioPlex
CEMIP2
Tbio
Novelty: 0.04698236
p_int: 0.987120486
p_ni: 0.012871676
p_wrong: 0.000007838
Score: 0.527
Data Source: BioPlex,STRINGDB
FUT11
Tbio
Family: Enzyme
Novelty: 0.16098097
p_int: 0.986416778
p_ni: 0.013583077
p_wrong: 1.45e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  284.19

PubMed score by year
PubTator Score  77.39

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer