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Tchem
CYP2C18
Cytochrome P450 2C18

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum but its specific substrate has not yet been determined. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. An additional gene, CYP2C17, was once thought to exist; however, CYP2C17 is now considered an artefact based on a chimera of CYP2C18 and CYP2C19. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285979
  • ENSP00000285979
  • ENSG00000108242
  • ENST00000339022
  • ENSP00000341293

Symbol
  • CPCI
  • CYP2C
  • CYP2C17
  • P450IIC17
  • P450-6B/29C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.95
gene perturbation
0.82
cell type or tissue
0.78
molecular function
0.73
microRNA
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 445.5   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 445.5   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
81.3
serum metabolite measurement
1
1
1
78.7
red blood cell distribution width
1
1
1
13.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
81.3
serum metabolite measurement
1
78.7
red blood cell distribution width
1
13.2
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cytochrome P450, family 2, subfamily C, polypeptide 18
701855
Horse
cytochrome P450 2C18
100061609
Horse
cytochrome P450 2C92
100061440
Cow
cytochrome P450, family 2, subfamily C, polypeptide 18
535243
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cytochrome P450, family 2, subfamily C, polypeptide 18
Horse
cytochrome P450 2C18
Horse
cytochrome P450 2C92
Cow
cytochrome P450, family 2, subfamily C, polypeptide 18
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P33260-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (15)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Metabolism
Reactome
Phase I - Functionalization of compounds
Reactome
Xenobiotics
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytochrome P450 - arranged by substrate type
Metabolism
Phase I - Functionalization of compounds
Xenobiotics
Gene Ontology Terms (17)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (81)
1 – 10 of 81
CYP2C9
Tchem
Novelty: 0.00041914
p_int: 1
Score: 0.571
Data Source: BioPlex,STRINGDB
TMEM260
Tdark
Novelty: 0.31409768
p_int: 0.999999708
p_ni: 2.2e-8
p_wrong: 2.7e-7
Score: 0.269
Data Source: BioPlex,STRINGDB
SLC7A2
Tbio
Family: Transporter
Novelty: 0.02262224
p_int: 0.956366317
p_ni: 0.043621284
p_wrong: 0.000012399
Score: 0.204
Data Source: BioPlex,STRINGDB
EPHX1
Tchem
Family: Enzyme
Novelty: 0.00220169
Score: 0.951
Data Source: STRINGDB
CYP4A11
Tbio
Novelty: 0.01121493
Score: 0.941
Data Source: STRINGDB
CYP1A1
Tchem
Novelty: 0.0002404
Score: 0.924
Data Source: STRINGDB
AOX1
Tbio
Family: Enzyme
Novelty: 0.0025823
Score: 0.908
Data Source: STRINGDB
UGT1A1
Tchem
Family: Enzyme
Novelty: 0.00135044
Score: 0.844
Data Source: STRINGDB
UGT1A8
Tbio
Family: Enzyme
Novelty: 0.00135129
Score: 0.83
Data Source: STRINGDB
CYP3A4
Tclin
Family: Enzyme
Novelty: 0.00015515
Score: 0.828
Data Source: STRINGDB
Publication Statistics
PubMed Score  445.50

PubMed score by year
PubTator Score  119.53

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer