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Tbio
ERCC3
General transcription and DNA repair factor IIH helicase subunit XPB

Protein Classes
Protein Summary
Description
ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/ERCC3, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/ERCC3 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. This gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285398
  • ENSP00000285398
  • ENSG00000163161

Symbol
  • XPB
  • XPBC
  • XPB
  • BTF2
  • TTD2
  • GTF2H
  • RAD25
  • TFIIH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
biological process
0.97
histone modification site profile
0.9
disease perturbation
0.83
protein domain
0.73


Related Tools
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.2   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.2   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 45
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:95414
13872
Rat
RGD:1307139
291703
Dog
ERCC excision repair 3, TFIIH core complex helicase subunit
VGNC:40443
476105
Horse
ERCC excision repair 3, TFIIH core complex helicase subunit
VGNC:51454
100050708
Cow
ERCC excision repair 3, TFIIH core complex helicase subunit
VGNC:28570
507984
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
ERCC excision repair 3, TFIIH core complex helicase subunit
Horse
ERCC excision repair 3, TFIIH core complex helicase subunit
Cow
ERCC excision repair 3, TFIIH core complex helicase subunit
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P19447-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (53)
DNA Repair (R-HSA-73894)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 47
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
DNA Repair
Reactome
Disease
Reactome
Dual Incision in GG-NER
Reactome
Dual incision in TC-NER
Reactome
Epigenetic regulation of gene expression
Name
Explore in Pharos
Explore in Source
DNA Repair
Disease
Dual Incision in GG-NER
Dual incision in TC-NER
Epigenetic regulation of gene expression
Gene Ontology Terms (52)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (292)
1 – 10 of 292
GTF2H3
Tbio
Novelty: 0.08168167
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
GTF2H5
Tbio
Novelty: 0.03493285
p_int: 0.999999998
p_ni: 2e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
GTF2H1
Tbio
Novelty: 0.01736328
p_int: 0.999999986
p_ni: 1.4e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
GTF2H4
Tbio
Novelty: 0.03140561
p_int: 0.999999897
p_ni: 1.03e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
ERCC5
Tchem
Family: Enzyme
Novelty: 0.00819696
p_int: 0.999999884
p_ni: 1.7e-8
p_wrong: 9.8e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
CCNH
Tbio
Novelty: 0.00693072
p_int: 0.999999423
p_ni: 5.77e-7
Score: 0.999
Data Source: BioPlex,STRINGDB
ZNF143
Tbio
Family: TF
Novelty: 0.00622649
p_int: 0.999996955
p_ni: 0.000002929
p_wrong: 1.16e-7
Score: 0.292
Data Source: BioPlex,STRINGDB
BCR
Tclin
Novelty: 0.00127709
p_int: 0.999996151
p_ni: 0.000003847
p_wrong: 3e-9
Score: 0.559
Data Source: BioPlex,STRINGDB
GTF2H2
Tbio
Novelty: 0.02761619
p_int: 0.999966473
p_ni: 0.000033527
Score: 0.999
Data Source: BioPlex,STRINGDB
FGL1
Tbio
Novelty: 0.02650803
p_int: 0.999502315
p_ni: 0.000497685
Data Source: BioPlex
Publication Statistics
PubMed Score  97.20

PubMed score by year
PubTator Score  114.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer