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Tbio
SKA1
Spindle and kinetochore-associated protein 1

Protein Summary
Description
Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation (PubMed:17093495, PubMed:19289083, PubMed:23085020). Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint (PubMed:17093495). The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies (PubMed:19289083). The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner (PubMed:19289083). Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules (PubMed:23085020). In the complex, it mediates the interaction with microtubules (PubMed:19289083, PubMed:23085020).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000285116
  • ENSP00000285116
  • ENSG00000154839
  • ENST00000398452
  • ENSP00000381470
  • ENST00000417656
  • ENSP00000397222
  • ENST00000571751
  • ENSP00000458992
  • ENSG00000262634
  • ENST00000616604
  • ENSP00000478259
  • ENST00000633940
  • ENSP00000488815

Symbol
  • C18orf24
  • C18orf24
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
kinase perturbation
0.88
transcription factor perturbation
0.61
small molecule perturbation
0.6
cellular component
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.08   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 84   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.08   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 84   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
2
2
4
13.7
high density lipoprotein cholesterol measurement
2
1
2
11.6
phospholipid measurement
1
2
2
7.3
phospholipid measurement
1
1
1
7
Items per page:
1 – 4 of 4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
4
13.7
high density lipoprotein cholesterol measurement
2
11.6
phospholipid measurement
2
7.3
phospholipid measurement
1
7
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
spindle and kinetochore associated complex subunit 1
700712
Mouse
MGI:1913718
66468
Rat
RGD:1310784
291441
Dog
spindle and kinetochore associated complex subunit 1
VGNC:46193
491691
Horse
spindle and kinetochore associated complex subunit 1
VGNC:22997
100069517
Species
Name
OMA
EggNOG
Inparanoid
Macaque
spindle and kinetochore associated complex subunit 1
Mouse
Rat
Dog
spindle and kinetochore associated complex subunit 1
Horse
spindle and kinetochore associated complex subunit 1
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (16)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (9)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (220)
1 – 10 of 220
SKA3
Tbio
Novelty: 0.05435653
p_int: 0.999999994
p_ni: 3e-9
p_wrong: 2e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
SNAP29
Tbio
Novelty: 0.02009206
p_int: 0.999998253
p_ni: 0.000001747
Score: 0.389
Data Source: BioPlex,STRINGDB
NAP1L5
Tbio
Novelty: 0.10378595
p_int: 0.999920977
p_ni: 0.000078292
p_wrong: 7.31e-7
Score: 0.183
Data Source: BioPlex,STRINGDB
PYCR2
Tbio
Family: Enzyme
Novelty: 0.05660996
p_int: 0.999908896
p_ni: 0.000089817
p_wrong: 0.000001288
Score: 0.672
Data Source: BioPlex,STRINGDB
FAM9C
Tdark
Novelty: 0.86727989
p_int: 0.999873584
p_ni: 0.000120941
p_wrong: 0.000005475
Data Source: BioPlex
PSMC5
Tbio
Family: Enzyme
Novelty: 0.01634039
p_int: 0.999823216
p_ni: 0.000176781
p_wrong: 2e-9
Data Source: BioPlex
BLOC1S6
Tbio
Novelty: 0.01845286
p_int: 0.999327221
p_ni: 0.000472718
p_wrong: 0.000200061
Score: 0.224
Data Source: BioPlex,STRINGDB
LHFPL2
Tdark
Novelty: 0.85421144
p_int: 0.999267938
p_ni: 0.000589432
p_wrong: 0.000142631
Data Source: BioPlex
PPP2R2C
Tbio
Family: Enzyme
Novelty: 0.05453128
p_int: 0.937741503
p_ni: 0.00059301
p_wrong: 0.061665487
Score: 0.558
Data Source: BioPlex,STRINGDB
SKA2
Tbio
Novelty: 0.03605487
Score: 0.998
Data Source: STRINGDB
Publication Statistics
PubMed Score  68.08

PubMed score by year
PubTator Score  31.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer