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Tchem
ADAMTS5
A disintegrin and metalloproteinase with thrombospondin motifs 5

Protein Classes
Protein Summary
Description
Metalloproteinase that plays an important role in connective tissue organization, development, inflammation, arthritis, and cell migration. ADAMTS5 is an extracellular matrix (ECM) degrading enzyme that show proteolytic activity toward the hyalectan group of chondroitin sulfate proteoglycans (CSPGs) including aggrecan, versican, brevican and neurocan (PubMed:16133547, PubMed:18992360). Cleavage within the hyalectans occurs at Glu-Xaa recognition motifs. Plays a role in embryonic development, including limb and cardiac morphogenesis, and skeletal muscle development through its versican remodeling properties. Participates in development of brown adipose tissue and browning of white adipose tissue. Plays an important role for T-lymphocyte migration from draining lymph nodes following viral infection. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, includi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284987
  • ENSP00000284987
  • ENSG00000154736

Symbol
  • ADAMTS11
  • ADMP2
  • ADMP-2
  • ADAM-TS5
  • ADAMTS-5
  • ADAMTS11
  • ADAM-TS 5
  • ADAMTS-11
  • ADAM-TS 11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
PubMedID
0.9
transcription factor perturbation
0.84
kinase perturbation
0.76
cell type or tissue
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.56   (req: < 5)
Gene RIFs: 80   (req: <= 3)
Antibodies: 473   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 265.56   (req: >= 5)
Gene RIFs: 80   (req: > 3)
Antibodies: 473   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 206
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
1
1
49.9
body height
1
1
1
24.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
1
49.9
body height
1
24.4
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (31)
Defective B3GALTL causes Peters-plus syndrome (PpS) (R-HSA-5083635)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B3GALTL causes Peters-plus syndrome (PpS)
Reactome
Degradation of the extracellular matrix
Reactome
Disease
Reactome
Diseases associated with O-glycosylation of proteins
Reactome
Diseases of glycosylation
Name
Explore in Pharos
Explore in Source
Defective B3GALTL causes Peters-plus syndrome (PpS)
Degradation of the extracellular matrix
Disease
Diseases associated with O-glycosylation of proteins
Diseases of glycosylation
Gene Ontology Terms (16)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (106)
1 – 10 of 106
ACAN
Tbio
Novelty: 0.00033695
Score: 0.993
Data Source: Reactome,STRINGDB
BCAN
Tbio
Novelty: 0.00737982
Score: 0.956
Data Source: STRINGDB
POFUT2
Tbio
Family: Enzyme
Novelty: 0.06236603
Score: 0.935
Data Source: STRINGDB
B3GLCT
Tbio
Family: Enzyme
Novelty: 0.02398944
Score: 0.929
Data Source: STRINGDB
ADAMTSL1
Tbio
Novelty: 0.08853044
Score: 0.927
Data Source: STRINGDB
ADAMTS2
Tbio
Family: Enzyme
Novelty: 0.00852208
Score: 0.923
Data Source: STRINGDB
THBS2
Tbio
Novelty: 0.00310724
Score: 0.923
Data Source: STRINGDB
ADAMTS3
Tbio
Family: Enzyme
Novelty: 0.00578975
Score: 0.923
Data Source: STRINGDB
SPON1
Tbio
Novelty: 0.01071398
Score: 0.922
Data Source: STRINGDB
ADAMTS13
Tbio
Family: Enzyme
Novelty: 0.0006095
Score: 0.921
Data Source: STRINGDB
Publication Statistics
PubMed Score  265.56

PubMed score by year
PubTator Score  182.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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