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Tbio
OLA1
Obg-like ATPase 1

Protein Summary
Description
Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP. This gene encodes a member of the GTPase protein family. The encoded protein interacts with breast cancer-associated gene 1 (BRCA1) and BRCA1-associated RING domain protein (BARD1), and is involved in centrosome regulation. Overexpression of this gene has been observed in multiple types of cancer and may be associated with poor survival. Pseudogenes of this gene have been defined on chromosomes 17 and 22. [provided by RefSeq, Jun 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284719
  • ENSP00000284719
  • ENSG00000138430
  • ENST00000344357
  • ENSP00000340167
  • ENST00000428402
  • ENSP00000410385

Symbol
  • GTPBP9
  • DOC45
  • GBP45
  • GTBP9
  • GTPBP9
  • PTD004
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
molecular function
0.99
protein domain
0.92
transcription factor perturbation
0.91
histone modification site profile
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.72   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 264   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 34.72   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 264   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
2
2
90.5
reaction time measurement
1
2
2
42.9
systolic blood pressure
1
1
1
31.1
grip strength measurement
1
1
1
14.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
90.5
reaction time measurement
2
42.9
systolic blood pressure
1
31.1
grip strength measurement
1
14.9
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (4)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Reactome
Platelet degranulation
Reactome
Response to elevated platelet cytosolic Ca2+
Name
Explore in Pharos
Explore in Source
Hemostasis
Platelet activation, signaling and aggregation
Platelet degranulation
Response to elevated platelet cytosolic Ca2+
Gene Ontology Terms (17)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (247)
1 – 10 of 247
ALDOA
Tbio
Family: Enzyme
Novelty: 0.00517474
Score: 0.913
Data Source: STRINGDB
FGB
Tbio
Novelty: 0.00437751
Score: 0.912
Data Source: STRINGDB
APP
Tchem
Novelty: 0.00008964
Score: 0.907
Data Source: STRINGDB
SCCPDH
Tbio
Family: Enzyme
Novelty: 0.06603568
Score: 0.907
Data Source: STRINGDB
NHLRC2
Tbio
Novelty: 0.18676651
Score: 0.902
Data Source: STRINGDB
VTI1B
Tbio
Novelty: 0.00955467
Score: 0.902
Data Source: STRINGDB
APOOL
Tbio
Novelty: 0.08233023
Score: 0.902
Data Source: STRINGDB
A2M
Tbio
Novelty: 0.00070446
Score: 0.902
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.902
Data Source: STRINGDB
CLU
Tbio
Novelty: 0.00054776
Score: 0.901
Data Source: STRINGDB
Publication Statistics
PubMed Score  34.72

PubMed score by year
PubTator Score  16.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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