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Tbio
NEIL2
Endonuclease 8-like 2

Protein Summary
Description
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284503
  • ENSP00000284503
  • ENSG00000154328
  • ENST00000403422
  • ENSP00000384070
  • ENST00000436750
  • ENSP00000394023
  • ENST00000455213
  • ENSP00000397538
  • ENST00000528323
  • ENSP00000435657

Symbol
  • NEH2
  • NEI2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
histone modification site profile
0.82
tissue
0.69
cell type or tissue
0.62
cellular component
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.23   (req: < 5)
Gene RIFs: 27   (req: <= 3)
Antibodies: 133   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 73.23   (req: >= 5)
Gene RIFs: 27   (req: > 3)
Antibodies: 133   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
1
1
49
Calcium channel blocker use measurement
1
1
1
11.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
apolipoprotein A 1 measurement
1
49
Calcium channel blocker use measurement
1
11.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nei like DNA glycosylase 2
VGNC:14547
463992
Macaque
nei like DNA glycosylase 2
696647
Mouse
MGI:2686058
382913
Rat
RGD:1312033
305957
Dog
nei like DNA glycosylase 2
VGNC:43727
486078
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nei like DNA glycosylase 2
Macaque
nei like DNA glycosylase 2
Mouse
Rat
Dog
nei like DNA glycosylase 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q969S2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (9)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (R-HSA-5649702)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Reactome
Base Excision Repair
Reactome
Base-Excision Repair, AP Site Formation
Reactome
Cleavage of the damaged pyrimidine
Reactome
DNA Repair
Name
Explore in Pharos
Explore in Source
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Base Excision Repair
Base-Excision Repair, AP Site Formation
Cleavage of the damaged pyrimidine
DNA Repair
Gene Ontology Terms (14)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (47)
1 – 10 of 47
NEIL1
Tbio
Family: Enzyme
Novelty: 0.00683956
Score: 0.991
Data Source: STRINGDB
OGG1
Tbio
Family: Enzyme
Novelty: 0.00074509
Score: 0.983
Data Source: STRINGDB
XRCC1
Tbio
Novelty: 0.00084203
Score: 0.977
Data Source: STRINGDB
PNKP
Tbio
Family: Enzyme
Novelty: 0.01038571
Score: 0.963
Data Source: STRINGDB
LIG3
Tbio
Family: Enzyme
Novelty: 0.00809038
Score: 0.953
Data Source: STRINGDB
POLB
Tchem
Family: Enzyme
Novelty: 0.00145102
Score: 0.948
Data Source: STRINGDB
KEAP1
Tclin
Novelty: 0.00062812
Score: 0.913
Data Source: STRINGDB
NTHL1
Tbio
Family: Enzyme
Novelty: 0.00769394
Score: 0.874
Data Source: STRINGDB
APEX1
Tchem
Family: Enzyme
Novelty: 0.00037532
Score: 0.701
Data Source: STRINGDB
CUL3
Tbio
Novelty: 0.0028737
Score: 0.692
Data Source: STRINGDB
Publication Statistics
PubMed Score  73.23

PubMed score by year
PubTator Score  44.32

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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