You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
CERS3
Ceramide synthase 3

Protein Summary
Description
Has (dihydro)ceramide synthesis activity with relatively broad substrate specificity, but a preference for C18:0 and other middle- to long-chain fatty acyl-CoAs (By similarity). It is crucial for the synthesis of very long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation. This gene is a member of the ceramide synthase family of genes. The ceramide synthase enzymes regulate sphingolipid synthesis by catalyzing the formation of ceramides from sphingoid base and acyl-coA substrates. This family member is involved in the synthesis of ceramides with ultra-long-chain acyl moieties (ULC-Cers), important to the epidermis in its role in creating a protective barrier from the environment. The protein encoded by this gene has also been implicated in modification of the lipid structures required for spermatogenesis. Mutations in this gene have been associated with male fertility defects, and epidermal defects, including ichthyosis. Alternative ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284382
  • ENSP00000284382
  • ENSG00000154227
  • ENST00000394113
  • ENSP00000377672
  • ENST00000538112
  • ENSP00000437640

Symbol
  • LASS3
  • ARCI9
  • LASS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
cell line
0.65
cellular component
0.63
microRNA
0.59
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.35   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 142   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.35   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 142   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
1
1
0
3.4
36.2
cotinine glucuronidation measurement
1
1
1
29.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
0
3.4
36.2
cotinine glucuronidation measurement
1
29.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ceramide synthase 3
VGNC:3566
453683
Macaque
ceramide synthase 3
693696
Mouse
MGI:2681008
545975
Rat
RGD:1564356
499174
Dog
ceramide synthase 3
VGNC:39149
607925
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ceramide synthase 3
Macaque
ceramide synthase 3
Mouse
Rat
Dog
ceramide synthase 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8IU89-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Sphingolipid de novo biosynthesis
Reactome
Sphingolipid metabolism
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
Sphingolipid de novo biosynthesis
Sphingolipid metabolism
Protein-Protein Interactions (57)
1 – 10 of 57
KDSR
Tbio
Family: Enzyme
Novelty: 0.0408411
Score: 0.958
Data Source: STRINGDB
UGCG
Tclin
Family: Enzyme
Novelty: 0.00481791
Score: 0.956
Data Source: STRINGDB
CERK
Tchem
Family: Kinase
Novelty: 0.0103948
Score: 0.951
Data Source: STRINGDB
UGT8
Tbio
Family: Enzyme
Novelty: 0.02518383
Score: 0.926
Data Source: STRINGDB
GALC
Tbio
Family: Enzyme
Novelty: 0.00203532
Score: 0.921
Data Source: STRINGDB
SMPD2
Tchem
Family: Enzyme
Novelty: 0.00375744
Score: 0.855
Data Source: STRINGDB
SGMS1
Tchem
Family: Enzyme
Novelty: 0.01717229
Score: 0.855
Data Source: STRINGDB
SMPD3
Tbio
Family: Enzyme
Novelty: 0.01053328
Score: 0.854
Data Source: STRINGDB
DEGS1
Tchem
Family: Enzyme
Novelty: 0.00300325
Score: 0.853
Data Source: STRINGDB
SGMS2
Tchem
Family: Enzyme
Novelty: 0.01360669
Score: 0.851
Data Source: STRINGDB
Publication Statistics
PubMed Score  25.35

PubMed score by year
PubTator Score  12.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: