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Tbio
ANKH
Progressive ankylosis protein homolog

Protein Summary
Description
Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. This gene encodes a multipass transmembrane protein that is expressed in joints and other tissues and controls pyrophosphate levels in cultured cells. Progressive ankylosis-mediated control of pyrophosphate levels has been suggested as a possible mechanism regulating tissue calcification and susceptibility to arthritis in higher animals. Mutations in this gene have been associated with autosomal dominant craniometaphyseal dysplasia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284268
  • ENSP00000284268
  • ENSG00000154122

Symbol
  • KIAA1581
  • ANK
  • CMDJ
  • HANK
  • MANK
  • CCAL2
  • CPPDD
  • SLC62A1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.98
kinase perturbation
0.97
transcription factor perturbation
0.8
small molecule perturbation
0.79
transcription factor binding site profile
0.76


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.59   (req: < 5)
Gene RIFs: 46   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.59   (req: >= 5)
Gene RIFs: 46   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
5
3
1.1
98.5
intraocular pressure measurement
3
3
3
90.8
protein measurement
1
1
1
79.4
blood metabolite measurement
1
1
1
79.4
amino acid measurement
1
1
1
79.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
98.5
intraocular pressure measurement
3
90.8
protein measurement
1
79.4
blood metabolite measurement
1
79.4
amino acid measurement
1
79.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ANKH inorganic pyrophosphate transport regulator
VGNC:11729
471459
Macaque
ANKH inorganic pyrophosphate transport regulator
717689
Mouse
MGI:3045421
11732
Rat
RGD:619925
114506
Dog
ANKH inorganic pyrophosphate transport regulator
VGNC:50869
491486
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ANKH inorganic pyrophosphate transport regulator
Macaque
ANKH inorganic pyrophosphate transport regulator
Mouse
Rat
Dog
ANKH inorganic pyrophosphate transport regulator
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9HCJ1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (2)
Miscellaneous transport and binding events (R-HSA-5223345)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Miscellaneous transport and binding events
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
Miscellaneous transport and binding events
Transport of small molecules
Protein-Protein Interactions (31)
1 – 10 of 31
ENPP4
Tbio
Family: Enzyme
Novelty: 0.09897251
p_int: 0.999045832
p_ni: 0.00007755
p_wrong: 0.000876618
Data Source: BioPlex
GAPDHS
Tbio
Family: Enzyme
Novelty: 0.00885959
p_int: 0.99825579
p_ni: 0.001740009
p_wrong: 0.000004201
Data Source: BioPlex
DUSP14
Tbio
Family: Enzyme
Novelty: 0.04013065
p_int: 0.995811767
p_ni: 0.004188227
p_wrong: 7e-9
Data Source: BioPlex
FAM234B
Tdark
Novelty: 1.53957047
p_int: 0.993246701
p_ni: 0.006753295
p_wrong: 4e-9
Data Source: BioPlex
SELENBP1
Tbio
Novelty: 0.00758018
p_int: 0.989384123
p_ni: 0.010615282
p_wrong: 5.94e-7
Data Source: BioPlex
DSG4
Tbio
Novelty: 0.01599371
p_int: 0.940917453
p_ni: 0.059035319
p_wrong: 0.000047227
Data Source: BioPlex
LRRC15
Tbio
Novelty: 0.03701624
p_int: 0.791121642
p_ni: 0.208878126
p_wrong: 2.32e-7
Data Source: BioPlex
TCHH
Tbio
Novelty: 0.00303837
p_int: 0.778172143
p_ni: 0.000012712
p_wrong: 0.221815145
Data Source: BioPlex
ENPP1
Tchem
Family: Enzyme
Novelty: 0.00256132
Score: 0.761
Data Source: STRINGDB
TAOK1
Tchem
Family: Kinase
Novelty: 0.01714291
Score: 0.653
Data Source: STRINGDB
Publication Statistics
PubMed Score  109.59

PubMed score by year
PubTator Score  97.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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