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Tbio
JPH3
Junctophilin-3

Protein Summary
Description
Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. JPH3 is brain-specific and appears to have an active role in certain neurons involved in motor coordination and memory. Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. CAG/CTG repeat expansion from normally 6-28 repeats to 40-59 repeats in the 3' UTR of thi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284262
  • ENSP00000284262
  • ENSG00000154118

Symbol
  • JP3
  • TNRC22
  • JP3
  • HDL2
  • JP-3
  • TNRC22
  • CAGL237
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.73
kinase perturbation
0.71
cellular component
0.67
tissue sample
0.67
microRNA
0.65


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.23   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 172   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.23   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 172   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
junctophilin 3
VGNC:13721
468063
Mouse
MGI:1891497
57340
Rat
RGD:1308416
307916
Dog
junctophilin 3
VGNC:42195
489669
Horse
junctophilin 3
VGNC:19228
100056257
Species
Name
OMA
EggNOG
Inparanoid
Chimp
junctophilin 3
Mouse
Rat
Dog
junctophilin 3
Horse
junctophilin 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q8WXH2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (16)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (64)
1 – 10 of 64
HSDL1
Tdark
Family: Enzyme
Novelty: 0.24066595
Score: 0.749
Data Source: STRINGDB
RYR1
Tclin
Family: IC
Novelty: 0.00077827
Score: 0.679
Data Source: STRINGDB
VPS13A
Tbio
Novelty: 0.00581335
Score: 0.626
Data Source: STRINGDB
CPED1
Tdark
Family: Enzyme
Novelty: 0.13549237
Score: 0.625
Data Source: STRINGDB
ADAM7
Tbio
Family: Enzyme
Novelty: 0.02387438
Score: 0.592
Data Source: STRINGDB
JPH4
Tbio
Novelty: 0.07699598
Score: 0.584
Data Source: STRINGDB
MAL
Tbio
Novelty: 0.03081736
Score: 0.579
Data Source: STRINGDB
SLC25A14
Tbio
Family: Transporter
Novelty: 0.02268116
Score: 0.578
Data Source: STRINGDB
OR10J3
Tdark
Family: oGPCR
Novelty: 2.28918072
Score: 0.575
Data Source: STRINGDB
MBNL1
Tbio
Novelty: 0.00441241
Score: 0.564
Data Source: STRINGDB
Publication Statistics
PubMed Score  59.23

PubMed score by year
PubTator Score  1019.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer