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Tbio
DGKE
Diacylglycerol kinase epsilon

Protein Classes
Protein Summary
Description
Highly selective for arachidonate-containing species of diacylglycerol (DAG). May terminate signals transmitted through arachidonoyl-DAG or may contribute to the synthesis of phospholipids with defined fatty acid composition. Diacylglycerol kinases are thought to be involved mainly in the regeneration of phosphatidylinositol (PI) from diacylglycerol in the PI-cycle during cell signal transduction. When expressed in mammalian cells, DGK-epsilon shows specificity for arachidonyl-containing diacylglycerol. DGK-epsilon is expressed predominantly in testis. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000284061
  • ENSP00000284061
  • ENSG00000153933
  • ENST00000572810
  • ENSP00000459295

Symbol
  • DAGK5
  • DGK
  • AHUS7
  • DAGK5
  • DAGK6
  • NPHS7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
histone modification site profile
0.83
metabolite
0.83
transcription factor binding site profile
0.73
microRNA
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.16   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 210   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.16   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 210   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (14)
Effects of PIP2 hydrolysis (R-HSA-114508)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Effects of PIP2 hydrolysis
Reactome
G alpha (q) signalling events
Reactome
GPCR downstream signalling
Reactome
Hemostasis
Reactome
Platelet activation, signaling and aggregation
Name
Explore in Pharos
Explore in Source
Effects of PIP2 hydrolysis
G alpha (q) signalling events
GPCR downstream signalling
Hemostasis
Platelet activation, signaling and aggregation
Gene Ontology Terms (20)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (79)
1 – 10 of 79
HEATR3
Tbio
Novelty: 0.08717658
p_int: 0.844828804
p_ni: 0.155171196
Data Source: BioPlex
PLD1
Tchem
Family: Enzyme
Novelty: 0.00756297
Score: 0.786
Data Source: STRINGDB
PLD2
Tchem
Family: Enzyme
Novelty: 0.00368183
Score: 0.783
Data Source: STRINGDB
MBOAT2
Tbio
Family: Enzyme
Novelty: 0.03587281
Score: 0.78
Data Source: STRINGDB
CDS2
Tbio
Family: Enzyme
Novelty: 0.09958506
Score: 0.774
Data Source: STRINGDB
CDS1
Tbio
Family: Enzyme
Novelty: 0.06388642
Score: 0.773
Data Source: STRINGDB
PLCB1
Tbio
Family: Enzyme
Novelty: 0.00309091
Score: 0.742
Data Source: STRINGDB
PLCD3
Tbio
Family: Enzyme
Novelty: 0.05869019
Score: 0.732
Data Source: STRINGDB
PLCB2
Tbio
Family: Enzyme
Novelty: 0.00689922
Score: 0.726
Data Source: STRINGDB
PLCE1
Tbio
Family: Enzyme
Novelty: 0.00779856
Score: 0.709
Data Source: STRINGDB
Publication Statistics
PubMed Score  51.16

PubMed score by year
PubTator Score  29.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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