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Tbio
TXNDC11
Thioredoxin domain-containing protein 11

Protein Summary
Description
May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283033
  • ENSP00000283033
  • ENSG00000153066
  • ENST00000356957
  • ENSP00000349439

Symbol
  • EFP1
  • EFP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
transcription factor binding site profile
0.87
virus perturbation
0.72
virus
0.66
cell type or tissue
0.65


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.97   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 115   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.97   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 115   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
2
4
95.6
mean corpuscular volume
1
1
1
19.8
triglyceride measurement
1
1
1
18.4
red blood cell distribution width
1
1
1
15.1
mean reticulocyte volume
1
1
1
15.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
4
95.6
mean corpuscular volume
1
19.8
triglyceride measurement
1
18.4
red blood cell distribution width
1
15.1
mean reticulocyte volume
1
15.1
Gene Ontology Terms (3)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (67)
1 – 10 of 67
RBL1
Tbio
Novelty: 0.00228265
p_int: 0.999995441
p_ni: 0.000004559
Score: 0.773
Data Source: BioPlex,STRINGDB
RBL2
Tbio
Novelty: 0.00121893
p_int: 0.999584796
p_ni: 0.000413816
p_wrong: 0.000001388
Score: 0.554
Data Source: BioPlex,STRINGDB
SYCE1
Tbio
Novelty: 0.05038876
p_int: 0.99928169
p_ni: 0.00071831
Data Source: BioPlex
TXLNA
Tbio
Novelty: 0.02549959
p_int: 0.999237925
p_ni: 0.000762075
Data Source: BioPlex
USO1
Tbio
Novelty: 0.02066669
p_int: 0.997594541
p_ni: 0.002405459
Score: 0.261
Data Source: BioPlex,STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
p_int: 0.995742706
p_ni: 0.004255897
p_wrong: 0.000001398
Score: 0.64
Data Source: BioPlex,STRINGDB
EDEM2
Tbio
Family: Enzyme
Novelty: 0.1180208
p_int: 0.972572098
p_ni: 0.027427902
Score: 0.887
Data Source: BioPlex,STRINGDB
CHST8
Tbio
Family: Enzyme
Novelty: 0.03489772
p_int: 0.965744589
p_ni: 0.034255411
Data Source: BioPlex
PCNT
Tbio
Novelty: 0.00369505
p_int: 0.96450803
p_ni: 0.03549197
Data Source: BioPlex
FBLN7
Tbio
Novelty: 0.03423924
p_int: 0.929305797
p_ni: 0.070694201
p_wrong: 2e-9
Score: 0.702
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  14.97

PubMed score by year
PubTator Score  8.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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