You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
GGPS1
Geranylgeranyl pyrophosphate synthase

Protein Summary
Description
Catalyzes the trans-addition of the three molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate, an important precursor of carotenoids and geranylated proteins. This gene is a member of the prenyltransferase family and encodes a protein with geranylgeranyl diphosphate (GGPP) synthase activity. The enzyme catalyzes the synthesis of GGPP from farnesyl diphosphate and isopentenyl diphosphate. GGPP is an important molecule responsible for the C20-prenylation of proteins and for the regulation of a nuclear hormone receptor. Alternate transcriptional splice variants, both protein-coding and non-protein-coding, have been found for this gene. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282841
  • ENSP00000282841
  • ENSG00000152904
  • ENST00000358966
  • ENSP00000351852
  • ENST00000391855
  • ENSP00000375728
  • ENST00000488594
  • ENSP00000418690

Symbol
  • GGPPS
  • GGPPS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.96
virus perturbation
0.85
histone modification site profile
0.83
transcription factor binding site profile
0.83
disease perturbation
0.79


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.63   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 408   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 213.63   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 408   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 40
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (5)
1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Activation of gene expression by SREBF (SREBP) (R-HSA-2426168)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of gene expression by SREBF (SREBP)
Reactome
Cholesterol biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Metabolism of steroids
Name
Explore in Pharos
Explore in Source
Activation of gene expression by SREBF (SREBP)
Cholesterol biosynthesis
Metabolism
Metabolism of lipids
Metabolism of steroids
Protein-Protein Interactions (95)
1 – 10 of 95
CCL26
Tbio
Novelty: 0.00781664
p_int: 0.99952292
p_ni: 0.000477075
p_wrong: 5e-9
Data Source: BioPlex
MFAP5
Tbio
Novelty: 0.02976267
p_int: 0.997307225
p_ni: 0.002692768
p_wrong: 7e-9
Data Source: BioPlex
TUSC1
Tbio
Novelty: 0.16326531
p_int: 0.996405899
p_ni: 6.4e-8
p_wrong: 0.003594037
Score: 0.513
Data Source: BioPlex,STRINGDB
IGF2
Tbio
Novelty: 0.00024884
p_int: 0.994446901
p_ni: 0.005553098
p_wrong: 2e-9
Data Source: BioPlex
CCDC69
Tdark
Novelty: 1.02272727
p_int: 0.991957379
p_ni: 0.008042585
p_wrong: 3.5e-8
Data Source: BioPlex
ODAPH
Tbio
Novelty: 0.49135043
p_int: 0.991773298
p_ni: 0.0082267
p_wrong: 2e-9
Data Source: BioPlex
TULP3
Tbio
Family: TF
Novelty: 0.0888983
p_int: 0.989476294
p_ni: 0.010523705
p_wrong: 1e-9
Data Source: BioPlex
IQGAP1
Tbio
Family: Enzyme
Novelty: 0.00482573
p_int: 0.986207705
p_ni: 0.013792295
Data Source: BioPlex
FAM19A3
Tdark
Novelty: 0.43478261
p_int: 0.97440392
p_ni: 0.02559608
p_wrong: 1e-9
Data Source: BioPlex
SLTM
Tdark
Novelty: 0.18808777
p_int: 0.966329569
p_ni: 0.011082026
p_wrong: 0.022588405
Score: 0.239
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  213.63

PubMed score by year
PubTator Score  50.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNS
1-70
KLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPT
70-140
EEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTE
140-210
GKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGG
210-280
NPELVALVKHLSKMFKEENE
280-300
MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIIIEVTEMLHNASLLIDDIEDNSKLRRGFPVAHSIYGIPSVINSANYVYFLGLEKVLTLDHPDAVKLFTRQLLELHQGQGLDIYWRDNYTCPTEEEYKAMVLQKTGGLFGLAVGLMQLFSDYKEDLKPLLNTLGLFFQIRDDYANLHSKEYSENKSFCEDLTEGKFSFPTIHAIWSRPESTQVQNILRQRTENIDIKKYCVHYLEDVGSFEYTRNTLKELEAKAYKQIDARGGNPELVALVKHLSKMFKEENE