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Tbio
SETBP1
SET-binding protein

Protein Summary
Description
This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000282030
  • ENSP00000282030
  • ENSG00000152217
  • ENST00000426838
  • ENSP00000390687
  • ENST00000649279
  • ENSP00000497406

Symbol
  • KIAA0437
  • SEB
  • MRD29
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.95
phenotype
0.77
trait
0.75
disease
0.69
PubMedID
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.02   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 257.02   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein-Protein Interactions (121)
1 – 10 of 121
TST
Tbio
Family: Enzyme
Novelty: 0.00283647
Score: 0.86
Data Source: STRINGDB
FUT2
Tbio
Family: Enzyme
Novelty: 0.00082764
Score: 0.84
Data Source: STRINGDB
EPHX2
Tchem
Family: Enzyme
Novelty: 0.00298106
Score: 0.84
Data Source: STRINGDB
EDNRB
Tclin
Family: GPCR
Novelty: 0.00055047
Score: 0.782
Data Source: STRINGDB
ASXL1
Tbio
Family: Epigenetic
Novelty: 0.00475904
Score: 0.766
Data Source: STRINGDB
CCDC6
Tbio
Novelty: 0.01216915
Score: 0.762
Data Source: STRINGDB
BPTF
Tchem
Family: Epigenetic
Novelty: 0.0141923
Score: 0.761
Data Source: STRINGDB
SELENOO
Tdark
Novelty: 0.03177082
Score: 0.758
Data Source: STRINGDB
TRIP12
Tbio
Family: Enzyme
Novelty: 0.00653395
Score: 0.719
Data Source: STRINGDB
SELENOK
Tbio
Novelty: 0.03305001
Score: 0.718
Data Source: STRINGDB
Publication Statistics
PubMed Score  257.02

PubMed score by year
PubTator Score  285.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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