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Tbio
MYCN
N-myc proto-oncogene protein

Protein Summary
Description
Positively regulates the transcription of MYCNOS in neuroblastoma cells. This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281043
  • ENSP00000281043
  • ENSG00000134323

Symbol
  • BHLHE37
  • NMYC
  • NMYC
  • ODED
  • MODED
  • N-myc
  • bHLHe37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
cell type or tissue
0.81
transcription factor perturbation
0.8
transcription factor binding site profile
0.77
microRNA
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2641.81   (req: < 5)
Gene RIFs: 315   (req: <= 3)
Antibodies: 321   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2641.81   (req: >= 5)
Gene RIFs: 315   (req: > 3)
Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
1
2
45.1
monocyte count
1
1
1
13.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
2
45.1
monocyte count
1
13.8
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MYCN proto-oncogene, bHLH transcription factor
459043
Mouse
MGI:97357
18109
Rat
RGD:1584995
298894
Cow
MYCN proto-oncogene, bHLH transcription factor
616888
Pig
MYCN proto-oncogene, bHLH transcription factor
100518190
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MYCN proto-oncogene, bHLH transcription factor
Mouse
Rat
Cow
MYCN proto-oncogene, bHLH transcription factor
Pig
MYCN proto-oncogene, bHLH transcription factor
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P04198-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (16)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (219)
1 – 10 of 219
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
Score: 0.976
Data Source: STRINGDB
NDRG1
Tbio
Novelty: 0.00352631
Score: 0.919
Data Source: STRINGDB
ALK
Tclin
Family: Kinase
Novelty: 0.00022375
Score: 0.849
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.846
Data Source: STRINGDB
SIRT1
Tchem
Family: Epigenetic
Novelty: 0.00022265
Score: 0.808
Data Source: STRINGDB
SHH
Tchem
Novelty: 0.00028347
Score: 0.802
Data Source: STRINGDB
CDKN2A
Tbio
Novelty: 0.00014147
Score: 0.799
Data Source: STRINGDB
CDKN2A
Tbio
Family: Enzyme
Novelty: 0.00014147
Score: 0.799
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.788
Data Source: STRINGDB
LIN28B
Tbio
Family: TF
Novelty: 0.00564546
Score: 0.772
Data Source: STRINGDB
Publication Statistics
PubMed Score  2641.81

PubMed score by year
PubTator Score  1950.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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