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Tchem
SLC7A11
Cystine/glutamate transporter

Protein Summary
Description
Sodium-independent, high-affinity exchange of anionic amino acids with high specificity for anionic form of cystine and glutamate. This gene encodes a member of a heteromeric, sodium-independent, anionic amino acid transport system that is highly specific for cysteine and glutamate. In this system, designated Xc(-), the anionic form of cysteine is transported in exchange for glutamate. This protein has been identified as the predominant mediator of Kaposi sarcoma-associated herpesvirus fusion and entry permissiveness into cells. Also, increased expression of this gene in primary gliomas (compared to normal brain tissue) was associated with increased glutamate secretion via the XCT channels, resulting in neuronal cell death. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280612
  • ENSP00000280612
  • ENSG00000151012

Symbol
  • xCT
  • CCBR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
small molecule perturbation
1
microRNA
0.92
molecular function
0.91
transcription factor perturbation
0.8


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 477.46   (req: < 5)
Gene RIFs: 64   (req: <= 3)
Antibodies: 301   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 477.46   (req: >= 5)
Gene RIFs: 64   (req: > 3)
Antibodies: 301   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 13
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (13)
1 – 10 of 13
CHEMBL279956
chemical structure image
CHEMBL401989
chemical structure image
CHEMBL3629574
chemical structure image
CHEMBL3629580
chemical structure image
CHEMBL3629670
chemical structure image
CHEMBL3629575
chemical structure image
CHEMBL3629577
chemical structure image
CHEMBL3629576
chemical structure image
CHEMBL3629671
chemical structure image
CHEMBL3629578
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
70.4
depressive symptom measurement
1
1
1
58.8
eosinophil percentage of leukocytes
1
1
1
25.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
70.4
depressive symptom measurement
1
58.8
eosinophil percentage of leukocytes
1
25.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 11
VGNC:50362
471310
Macaque
solute carrier family 7 member 11
696516
Mouse
MGI:1347355
26570
Rat
RGD:1309275
310392
Dog
solute carrier family 7 member 11
VGNC:46472
483821
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 7 member 11
Macaque
solute carrier family 7 member 11
Mouse
Rat
Dog
solute carrier family 7 member 11
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UPY5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Amino acid transport across the plasma membrane (R-HSA-352230)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amino acid transport across the plasma membrane
Reactome
Basigin interactions
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Reactome
SLC-mediated transmembrane transport
Name
Explore in Pharos
Explore in Source
Amino acid transport across the plasma membrane
Basigin interactions
Cell surface interactions at the vascular wall
Hemostasis
SLC-mediated transmembrane transport
Protein-Protein Interactions (63)
1 – 10 of 63
SLC3A2
Tbio
Family: Transporter
Novelty: 0.0021506
Score: 0.994
Data Source: Reactome,STRINGDB
BSG
Tbio
Novelty: 0.0010285
Score: 0.91
Data Source: STRINGDB
NFE2L2
Tchem
Family: TF
Novelty: 0.00043828
Score: 0.736
Data Source: STRINGDB
ATF4
Tbio
Family: TF
Novelty: 0.00253408
Score: 0.732
Data Source: STRINGDB
SLC1A2
Tchem
Family: Transporter
Novelty: 0.00086733
Score: 0.728
Data Source: STRINGDB
SLC1A7
Tchem
Family: Transporter
Novelty: 0.00067678
Score: 0.697
Data Source: STRINGDB
GCLM
Tbio
Family: Enzyme
Novelty: 0.00395815
Score: 0.679
Data Source: STRINGDB
CD44
Tbio
Novelty: 0.00011321
Score: 0.659
Data Source: STRINGDB
SLC1A5
Tchem
Family: Transporter
Novelty: 0.00201741
Score: 0.658
Data Source: STRINGDB
KYNU
Tchem
Family: Enzyme
Novelty: 0.01372383
Score: 0.656
Data Source: STRINGDB
Publication Statistics
PubMed Score  477.46

PubMed score by year
PubTator Score  234.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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