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Tbio
DENR
Density-regulated protein

Protein Summary
Description
May be involved in the translation of target mRNAs by scanning and recognition of the initiation codon. Involved in translation initiation; promotes recruitmnet of aminoacetyled initiator tRNA to P site of 40S ribosomes. Can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. Plays a role in the modulation of the translational profile of a subset of cancer-related mRNAs when recruited to the translational initiation complex by the oncogene MCTS1. This gene encodes a protein whose expression was found to increase in cultured cells at high density but not during growth arrest. This gene was also shown to have increased expression in cells overexpressing HER-2/neu proto-oncogene. The protein contains an SUI1 domain. In budding yeast, SUI1 is a translation initiation factor that along with eIF-2 and the initiator tRNA-Met, directs the ribosome to the proper translation start site ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280557
  • ENSP00000280557
  • ENSG00000139726

Symbol
  • DRP1
  • DRP
  • DRP1
  • SMAP-3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
virus perturbation
0.83
transcription factor binding site profile
0.82
histone modification site profile
0.8
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.29   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 179   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 163.29   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 179   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (6)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (181)
1 – 10 of 181
MCTS1
Tbio
Novelty: 0.07039427
p_int: 0.999999991
p_ni: 9e-9
Score: 0.998
Data Source: BioPlex,STRINGDB
DOCK11
Tdark
Novelty: 0.0295159
p_int: 0.999999477
p_ni: 5.23e-7
Score: 0.183
Data Source: BioPlex,STRINGDB
NTMT1
Tbio
Family: Enzyme
Novelty: 0.06322967
p_int: 0.999996889
p_ni: 0.00000311
p_wrong: 2e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
RB1CC1
Tbio
Novelty: 0.00744817
p_int: 0.999971327
p_ni: 0.000028673
Data Source: BioPlex
ATG13
Tbio
Novelty: 0.00951471
p_int: 0.999773282
p_ni: 0.000140884
p_wrong: 0.000085834
Score: 0.189
Data Source: BioPlex,STRINGDB
COPS5
Tbio
Novelty: 0.00406225
p_int: 0.999309395
p_ni: 0.000690605
Score: 0.575
Data Source: BioPlex,STRINGDB
DHTKD1
Tbio
Family: Enzyme
Novelty: 0.0381406
p_int: 0.997285543
p_ni: 0.002714441
p_wrong: 1.6e-8
Score: 0.165
Data Source: BioPlex,STRINGDB
NSUN4
Tbio
Family: Enzyme
Novelty: 0.15593771
p_int: 0.99699394
p_ni: 0.00300604
p_wrong: 2.1e-8
Data Source: BioPlex
SNRNP27
Tbio
Novelty: 0.0175187
p_int: 0.996402254
p_ni: 0.003597648
p_wrong: 9.8e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
COPS2
Tbio
Novelty: 0.03509351
p_int: 0.979233191
p_ni: 0.020766809
Score: 0.565
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  163.29

PubMed score by year
PubTator Score  14.31

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer