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Tbio
CCT5
T-complex protein 1 subunit epsilon

Protein Summary
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Mutations in this gene cause hereditary se ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280326
  • ENSP00000280326
  • ENSG00000150753
  • ENST00000506600
  • ENSP00000423052

Symbol
  • CCTE
  • KIAA0098
  • CCTE
  • HEL-S-69
  • PNAS-102
  • CCT-epsilon
  • TCP-1-epsilon
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
hub protein
0.98
disease perturbation
0.97
co-expressed gene
0.96


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.27   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 305   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.27   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 305   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chaperonin containing TCP1 subunit 5
VGNC:6837
461721
Macaque
chaperonin containing TCP1 subunit 5
696640
Mouse
MGI:107185
12465
Rat
RGD:735161
294864
Dog
chaperonin containing TCP1 subunit 5
VGNC:38925
606873
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chaperonin containing TCP1 subunit 5
Macaque
chaperonin containing TCP1 subunit 5
Mouse
Rat
Dog
chaperonin containing TCP1 subunit 5
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48643-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Chaperonin-mediated protein folding
Reactome
Cilium Assembly
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Chaperonin-mediated protein folding
Cilium Assembly
Gene Ontology Terms (23)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CAFA
Inferred from Direct Assay (IDA)
CAFA
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (520)
1 – 10 of 520
WDR70
Tdark
Novelty: 0.37521871
p_int: 0.999982809
p_ni: 0.000017191
Data Source: BioPlex
DCAF12
Tbio
Novelty: 0.15472702
p_int: 0.99988252
p_ni: 0.000051509
p_wrong: 0.000065971
Data Source: BioPlex
KATNB1
Tbio
Novelty: 0.08472625
p_int: 0.999822067
p_ni: 0.000177863
p_wrong: 7e-8
Data Source: BioPlex
KATNA1
Tbio
Family: Enzyme
Novelty: 0.05656063
p_int: 0.999815151
p_ni: 0.00018475
p_wrong: 9.9e-8
Data Source: BioPlex
KLHL8
Tdark
Novelty: 0.4838314
p_int: 0.999756228
p_ni: 0.000243469
p_wrong: 3.03e-7
Data Source: BioPlex
DTL
Tbio
Novelty: 0.01659105
p_int: 0.999693808
p_ni: 0.000306192
Score: 0.19
Data Source: BioPlex,STRINGDB
TUBD1
Tbio
Novelty: 0.03591414
p_int: 0.999316861
p_ni: 0.000327605
p_wrong: 0.000355534
Data Source: BioPlex
DCAF13
Tbio
Novelty: 0.02796363
p_int: 0.998212944
p_ni: 0.001750527
p_wrong: 0.000036529
Score: 0.317
Data Source: BioPlex,STRINGDB
KLHDC8B
Tbio
Novelty: 0.15409379
p_int: 0.997816509
p_ni: 0.000003897
p_wrong: 0.002179594
Data Source: BioPlex
RFWD3
Tbio
Family: Enzyme
Novelty: 0.0859205
p_int: 0.997782222
p_ni: 0.002217618
p_wrong: 1.6e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  39.27

PubMed score by year
PubTator Score  17.69

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer