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Tclin
ADRA2A
Alpha-2A adrenergic receptor

Protein Summary
Description
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280155
  • ENSP00000280155
  • ENSG00000150594

Symbol
  • ADRA2R
  • ADRAR
  • ADRA2
  • ADRAR
  • ZNF32
  • ADRA2R
  • ALPHA2AAR
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug
1
molecular function
0.96
ligand (chemical)
0.94
PubMedID
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.92   (req: < 5)
Gene RIFs: 124   (req: <= 3)
Antibodies: 292   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 351.92   (req: >= 5)
Gene RIFs: 124   (req: > 3)
Antibodies: 292   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 49
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 326
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 44
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (25)
Adrenaline signalling through Alpha-2 adrenergic receptor (R-HSA-392023)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adrenaline signalling through Alpha-2 adrenergic receptor
Reactome
Adrenaline,noradrenaline inhibits insulin secretion
Reactome
Adrenoceptors
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Name
Explore in Pharos
Explore in Source
Adrenaline signalling through Alpha-2 adrenergic receptor
Adrenaline,noradrenaline inhibits insulin secretion
Adrenoceptors
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
Gene Ontology Terms (54)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (330)
1 – 10 of 330
NPY
Tbio
Novelty: 0.00012637
Score: 0.965
Data Source: STRINGDB
CNR1
Tclin
Family: GPCR
Novelty: 0.00060063
Score: 0.962
Data Source: STRINGDB
GNAI2
Tbio
Novelty: 0.03014729
Score: 0.956
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.956
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.954
Data Source: STRINGDB
TMIGD3
Tchem
Novelty: 0.00089511
Score: 0.953
Data Source: STRINGDB
ADORA3
Tchem
Family: GPCR
Novelty: 0.00089511
Score: 0.953
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.95
Data Source: Reactome,STRINGDB
GNG2
Tbio
Novelty: 0.04807242
Score: 0.949
Data Source: Reactome,STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
Score: 0.949
Data Source: STRINGDB
Publication Statistics
PubMed Score  351.92

PubMed score by year
PubTator Score  331.56

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer