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Tchem
HNMT
Histamine N-methyltransferase

Protein Summary
Description
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280096
  • ENSP00000280096
  • ENSG00000150540
  • ENST00000280097
  • ENSP00000280097
  • ENST00000329366
  • ENSP00000333259
  • ENST00000410115
  • ENSP00000386940
  • ENST00000475675
  • ENSP00000419415

Symbol
  • HMT
  • MRT51
  • HNMT-S1
  • HNMT-S2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
PubMedID
0.81
microRNA
0.72
disease
0.68
phenotype
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 988.84   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 286   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 988.84   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
amodiaquine
chemical structure image
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histamine N-methyltransferase
VGNC:10833
742204
Macaque
histamine N-methyltransferase-like
703857
Mouse
MGI:2153181
140483
Rat
RGD:71049
81676
Dog
histamine N-methyltransferase
VGNC:54805
476133
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histamine N-methyltransferase
Macaque
histamine N-methyltransferase-like
Mouse
Rat
Dog
histamine N-methyltransferase
Protein Data Bank (8)
1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Histidine catabolism (R-HSA-70921)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Histidine catabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Reactome
Selenoamino acid metabolism
Name
Explore in Pharos
Explore in Source
Histidine catabolism
Metabolism
Metabolism of amino acids and derivatives
Metabolism of ingested SeMet, Sec, MeSec into H2Se
Selenoamino acid metabolism
Gene Ontology Terms (10)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (81)
1 – 10 of 81
HDC
Tbio
Family: Enzyme
Novelty: 0.00193646
Score: 0.98
Data Source: STRINGDB
AOC1
Tchem
Family: Enzyme
Novelty: 0.00146464
Score: 0.977
Data Source: STRINGDB
MAOA
Tclin
Family: Enzyme
Novelty: 0.00031037
Score: 0.946
Data Source: STRINGDB
MAOB
Tclin
Family: Enzyme
Novelty: 0.00030366
Score: 0.942
Data Source: STRINGDB
SETD1A
Tbio
Family: Epigenetic
Novelty: 0.00248544
Score: 0.826
Data Source: STRINGDB
HCFC1
Tbio
Novelty: 0.00440762
Score: 0.724
Data Source: STRINGDB
SETD1B
Tbio
Family: Epigenetic
Novelty: 0.03331663
Score: 0.71
Data Source: STRINGDB
SETD2
Tchem
Family: Epigenetic
Novelty: 0.00178899
Score: 0.695
Data Source: STRINGDB
EHMT2
Tchem
Family: Epigenetic
Novelty: 0.00262578
Score: 0.669
Data Source: STRINGDB
EZH2
Tclin
Family: Epigenetic
Novelty: 0.00052816
Score: 0.669
Data Source: STRINGDB
Publication Statistics
PubMed Score  988.84

PubMed score by year
PubTator Score  400.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer