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Tbio
MIA2
Melanoma inhibitory activity protein 2

Protein Summary
Description
Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic reticulum. Isoform 1 plays a role in the secretion of lipoproteins, pre-chylomicrons and pre-VLDLs, by participating in their export from the endoplasmic reticulum (PubMed:27138255). Thereby, may play a role in cholesterol and triglyceride homeostasis (By similarity). This gene encodes s receptor in the endoplasmic reticulum, which plays a role in the export of large pre-chylomicrons and pre-very low density lipoproteins (pre-VLDLs). Three major classes of transcripts are generated from this gene- melanoma inhibitory activity 2-specific transcripts, cTAGE family member 5-specific transcripts and transcripts that include exons from both these transcript species (TANGO1-like or TALI). Additionally, alternative splicing in these transcripts results in multiple transcript variants encod ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280082
  • ENSP00000280082
  • ENSG00000150527
  • ENST00000640607
  • ENSP00000491014

Symbol
  • MEA6
  • MGEA
  • TALI
  • MGEA6
  • CTAGE5
  • MGEA11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.83
disease perturbation
0.79
transcription factor binding site profile
0.73
transcription factor
0.71
cell type or tissue
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.45   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 119   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.45   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 119   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
1
1
5.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
systolic blood pressure
1
5.6
Pathways (8)
Asparagine N-linked glycosylation (R-HSA-446203)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Asparagine N-linked glycosylation
Reactome
Cargo concentration in the ER
Reactome
ER to Golgi Anterograde Transport
Reactome
Membrane Trafficking
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Asparagine N-linked glycosylation
Cargo concentration in the ER
ER to Golgi Anterograde Transport
Membrane Trafficking
Metabolism of proteins
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (33)
1 – 10 of 33
CLIC3
Tbio
Family: IC
Novelty: 0.07268934
p_int: 0.832830076
p_ni: 0.167092427
p_wrong: 0.000077497
Data Source: BioPlex
PREB
Tbio
Family: TF
Novelty: 0.00595167
Score: 0.806
Data Source: Reactome,STRINGDB
TRAPPC2
Tbio
Novelty: 0.02016231
Score: 0.707
Data Source: STRINGDB
SEC24B
Tbio
Novelty: 0.01031644
Score: 0.671
Data Source: STRINGDB
CCDC68
Tbio
Novelty: 0.1262502
Score: 0.668
Data Source: STRINGDB
KLHL12
Tbio
Novelty: 0.05789229
Score: 0.649
Data Source: STRINGDB
SEC16A
Tbio
Novelty: 0.02221416
Score: 0.646
Data Source: STRINGDB
SEC13
Tbio
Novelty: 0.00709413
Score: 0.62
Data Source: STRINGDB
SAR1B
Tbio
Family: Enzyme
Novelty: 0.02260817
Score: 0.592
Data Source: STRINGDB
SAR1A
Tbio
Family: Enzyme
Novelty: 0.0335242
Score: 0.563
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.45

PubMed score by year
PubTator Score  20.59

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer