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Tbio
ARID5B
AT-rich interactive domain-containing protein 5B

Protein Summary
Description
Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-336, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation. Represses the cytomegalovirus enhancer. This gene encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279873
  • ENSP00000279873
  • ENSG00000150347
  • ENST00000309334
  • ENSP00000308862

Symbol
  • DESRT
  • MRF2
  • MRF2
  • DESRT
  • MRF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
PubMedID
0.95
disease perturbation
0.87
phenotype
0.87
gene perturbation
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.36   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 59.36   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (6)
Chromatin modifying enzymes (R-HSA-3247509)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Chromatin modifying enzymes
Reactome
Chromatin organization
Reactome
HDMs demethylate histones
Name
Explore in Pharos
Explore in Source
Chromatin modifying enzymes
Chromatin organization
HDMs demethylate histones
Gene Ontology Terms (31)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GDB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (43)
1 – 10 of 43
HDAC1
Tclin
Family: Epigenetic
Novelty: 0.00083441
p_int: 0.999999348
p_ni: 6.51e-7
Score: 0.646
Data Source: BioPlex,STRINGDB
HIST1H2BA
Tbio
Novelty: 0.03503778
p_int: 0.999999127
p_ni: 8.73e-7
Score: 0.71
Data Source: BioPlex,STRINGDB
C16orf87
Tdark
p_int: 0.999998756
p_ni: 0.000001244
Score: 0.891
Data Source: BioPlex,STRINGDB
H2AFZ
Tbio
Novelty: 0.00281312
p_int: 0.999998383
p_ni: 0.000001611
p_wrong: 6e-9
Data Source: BioPlex
THSD4
Tbio
Novelty: 0.16828393
p_int: 0.840069595
p_ni: 0.15992997
p_wrong: 4.34e-7
Score: 0.188
Data Source: BioPlex,STRINGDB
PHF2
Tbio
Family: Epigenetic
Novelty: 0.16574586
Score: 0.956
Data Source: Reactome,STRINGDB
CEBPE
Tbio
Family: TF
Novelty: 0.01347316
Score: 0.738
Data Source: STRINGDB
IKZF1
Tbio
Family: TF
Novelty: 0.00201134
Score: 0.679
Data Source: STRINGDB
PIP4K2A
Tbio
Family: Kinase
Novelty: 0.01482796
Score: 0.677
Data Source: STRINGDB
ZFAND4
Tdark
Novelty: 0.27190332
Score: 0.625
Data Source: STRINGDB
Publication Statistics
PubMed Score  59.36

PubMed score by year
PubTator Score  45.42

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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