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Tdark
OCSTAMP
Osteoclast stimulatory transmembrane protein

Protein Summary
Description
Probable cell surface receptor that plays a role in cellular fusion and cell differentiation. Cooperates with DCSTAMP in modulating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Involved in osteoclast bone resorption. Promotes osteoclast differentiation and may play a role in the multinucleated osteoclast maturation (By similarity). The protein encoded by this gene is orthologous to the mouse osteoclast stimulatory transmembrane protein (OCSTAMP), which is a membrane-anchored cell surface receptor that promotes nucleation of osteoclasts. The mouse protein is also involved in bone resorption and osteoclast differentiation. [provided by RefSeq, Feb 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279028
  • ENSP00000279028
  • ENSG00000149635

Symbol
  • C20orf123
  • OC-STAMP
  • C20orf123
  • dJ257E24.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.88
gene perturbation
0.74
biological process
0.56
tissue
0.49
protein complex
0.4


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.34   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 14   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.34   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 14   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (7)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (17)
1 – 10 of 17
DCSTAMP
Tbio
Novelty: 0.01107838
Score: 0.855
Data Source: STRINGDB
CTSK
Tchem
Family: Enzyme
Novelty: 0.0007707
Score: 0.732
Data Source: STRINGDB
ATP6V0D2
Tbio
Family: Enzyme
Novelty: 0.0354396
Score: 0.721
Data Source: STRINGDB
ACP5
Tbio
Family: Enzyme
Novelty: 0.00034703
Score: 0.678
Data Source: STRINGDB
NFATC1
Tbio
Family: TF
Novelty: 0.00130337
Score: 0.661
Data Source: STRINGDB
TNFSF11
Tclin
Novelty: 0.00018328
Score: 0.655
Data Source: STRINGDB
OSCAR
Tbio
Novelty: 0.00176954
Score: 0.606
Data Source: STRINGDB
TNFRSF11A
Tbio
Novelty: 0.0056219
Score: 0.516
Data Source: STRINGDB
CSF1R
Tclin
Family: Kinase
Novelty: 0.00064143
Score: 0.495
Data Source: STRINGDB
S1PR4
Tclin
Family: GPCR
Novelty: 0.01523676
Score: 0.483
Data Source: STRINGDB
Publication Statistics
PubMed Score  12.34

PubMed score by year
PubTator Score  3.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer