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Tbio
SLC13A3
Solute carrier family 13 member 3

Protein Summary
Description
High-affinity sodium-dicarboxylate cotransporter that accepts a range of substrates with 4-5 carbon atoms. The stoichiometry is probably 3 Na(+) for 1 divalent succinate. Mammalian sodium-dicarboxylate cotransporters transport succinate and other Krebs cycle intermediates. They fall into 2 categories based on their substrate affinity: low affinity and high affinity. Both the low- and high-affinity transporters play an important role in the handling of citrate by the kidneys. The protein encoded by this gene represents the high-affinity form. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, although the full-length nature of some of them have not been characterized yet. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000279027
  • ENSP00000279027
  • ENSG00000158296
  • ENST00000290317
  • ENSP00000290317
  • ENST00000413164
  • ENSP00000415852
  • ENST00000472148
  • ENSP00000420177
  • ENST00000495082
  • ENSP00000419621

Symbol
  • NADC3
  • SDCT2
  • NADC3
  • SDCT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.84
microRNA
0.67
tissue
0.65
transcription factor
0.62
cellular component
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.68   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 118   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.68   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 118   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
2.1
66.8
glomerular filtration rate
1
1
0
12.2
51.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
2.1
66.8
glomerular filtration rate
0
12.2
51.4
Pathways (4)
SLC-mediated transmembrane transport (R-HSA-425407)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
SLC-mediated transmembrane transport
Reactome
Sodium-coupled sulphate, di- and tri-carboxylate transporters
Reactome
Transport of bile salts and organic acids, metal ions and amine compounds
Reactome
Transport of small molecules
Name
Explore in Pharos
Explore in Source
SLC-mediated transmembrane transport
Sodium-coupled sulphate, di- and tri-carboxylate transporters
Transport of bile salts and organic acids, metal ions and amine compounds
Transport of small molecules
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (46)
1 – 10 of 46
SLC5A12
Tdark
Family: Transporter
Novelty: 0.12119749
Score: 0.824
Data Source: STRINGDB
SLC15A5
Tdark
Family: Transporter
Novelty: 0.59784242
Score: 0.723
Data Source: STRINGDB
SLC5A2
Tclin
Family: Transporter
Novelty: 0.00066797
Score: 0.717
Data Source: STRINGDB
SLC22A6
Tclin
Family: Transporter
Novelty: 0.00389149
Score: 0.711
Data Source: STRINGDB
SLC22A8
Tclin
Family: Transporter
Novelty: 0.00291642
Score: 0.693
Data Source: STRINGDB
SLC26A2
Tbio
Family: Transporter
Novelty: 0.00325201
Score: 0.671
Data Source: STRINGDB
AGXT2
Tbio
Family: Enzyme
Novelty: 0.02018289
Score: 0.66
Data Source: STRINGDB
SLC5A11
Tchem
Family: Transporter
Novelty: 0.01085543
Score: 0.635
Data Source: STRINGDB
SLC26A3
Tbio
Family: Transporter
Novelty: 0.00157687
Score: 0.612
Data Source: STRINGDB
SLC25A17
Tbio
Family: Transporter
Novelty: 0.00601179
Score: 0.61
Data Source: STRINGDB
Publication Statistics
PubMed Score  38.68

PubMed score by year
PubTator Score  27.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer