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Tbio
CEP164
Centrosomal protein of 164 kDa

Protein Summary
Description
Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1. This gene encodes a centrosomal protein involved in microtubule organization, DNA damage response, and chromosome segregation. The encoded protein is required for assembly of primary cilia and localizes to mature centrioles. Defects in this gene are a cause of nephronophthisis-related ciliopathies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278935
  • ENSP00000278935
  • ENSG00000110274

Symbol
  • KIAA1052
  • NPHP15
  • NPHP15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.75
transcription factor
0.75
virus perturbation
0.68
cell line
0.64
transcription factor binding site profile
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.98   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.98   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
1
2
57.7
hemoglobin measurement
1
1
1
50.8
apolipoprotein A 1 measurement
1
1
1
20.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
57.7
hemoglobin measurement
1
50.8
apolipoprotein A 1 measurement
1
20.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 164
VGNC:3155
451575
Macaque
centrosomal protein 164
697948
Mouse
MGI:2384878
214552
Rat
RGD:1561243
363055
Dog
centrosomal protein 164
VGNC:39121
489389
Species
Name
OMA
EggNOG
Inparanoid
Chimp
centrosomal protein 164
Macaque
centrosomal protein 164
Mouse
Rat
Dog
centrosomal protein 164
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UPV0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (54)
AURKA Activation by TPX2 (R-HSA-8854518)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AURKA Activation by TPX2
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Centrosome maturation
Name
Explore in Pharos
Explore in Source
AURKA Activation by TPX2
Anchoring of the basal body to the plasma membrane
Cell Cycle
Cell Cycle, Mitotic
Centrosome maturation
Gene Ontology Terms (13)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (216)
1 – 10 of 216
DISC1
Tbio
Novelty: 0.00183442
p_int: 0.999718877
p_ni: 0.000280143
p_wrong: 9.8e-7
Data Source: BioPlex
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.999484792
p_ni: 0.000515202
p_wrong: 6e-9
Data Source: BioPlex
NCAPH2
Tbio
Novelty: 0.12134933
p_int: 0.998600134
p_ni: 0.001399851
p_wrong: 1.5e-8
Data Source: BioPlex
LIPH
Tbio
Family: Enzyme
Novelty: 0.00961658
p_int: 0.99351029
p_ni: 0.00648971
Score: 0.204
Data Source: BioPlex,STRINGDB
COP1
Tbio
Family: Enzyme
Novelty: 0.10908534
p_int: 0.9929091
p_ni: 0.005910091
p_wrong: 0.001180809
Data Source: BioPlex
FAM19A3
Tdark
Novelty: 0.37183557
p_int: 0.99234409
p_ni: 0.00765591
Data Source: BioPlex
RALBP1
Tbio
Novelty: 0.01525176
p_int: 0.99228934
p_ni: 0.006017873
p_wrong: 0.001692786
Data Source: BioPlex
THSD4
Tbio
Novelty: 0.12898073
p_int: 0.983495288
p_ni: 0.016041641
p_wrong: 0.000463071
Data Source: BioPlex
CRYL1
Tbio
Family: Enzyme
Novelty: 0.04513297
p_int: 0.954816289
p_ni: 0.044642154
p_wrong: 0.000541557
Data Source: BioPlex
CELA1
Tchem
Family: Enzyme
Novelty: 0.00290708
p_int: 0.941351412
p_ni: 0.05832997
p_wrong: 0.000318618
Score: 0.181
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  22.98

PubMed score by year
PubTator Score  14.17

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer