You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
TMEM138
Transmembrane protein 138

Protein Summary
Description
Required for ciliogenesis. This gene encodes a multi-pass transmembrane protein. Reduced expression of this gene in mouse fibroblasts causes short cilia and failure of ciliogenesis. Expression of this gene is tightly coordinated with expression of the neighboring gene TMEM216. Mutations in this gene are associated with the autosomal recessive neurodevelopmental disorder Joubert Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278826
  • ENSP00000278826
  • ENSG00000149483
  • ENST00000542946
  • ENSP00000445792

Symbol
  • HSPC196
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
tissue
0.72
transcription factor binding site profile
0.67
tissue sample
0.65
cellular component
0.54


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.38   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 30   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.38   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 30   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 138
VGNC:977
451236
Macaque
transmembrane protein 138
693905
Mouse
MGI:1920232
72982
Rat
RGD:735168
361728
Dog
transmembrane protein 216
100688144
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transmembrane protein 138
Macaque
transmembrane protein 138
Mouse
Rat
Dog
transmembrane protein 216
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9NPI0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Joubert Syndrome
WikiPathways
Joubert Syndrome
WikiPathways
Joubert Syndrome
WikiPathways
Joubert Syndrome
Name
Explore in Pharos
Explore in Source
Joubert Syndrome
Joubert Syndrome
Joubert Syndrome
Joubert Syndrome
Gene Ontology Terms (4)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (59)
1 – 10 of 59
TMEM231
Tbio
Novelty: 0.17100188
Score: 0.855
Data Source: STRINGDB
NPHP1
Tbio
Novelty: 0.01113034
Score: 0.841
Data Source: STRINGDB
TMEM216
Tbio
Novelty: 0.07870718
Score: 0.807
Data Source: STRINGDB
CEP41
Tbio
Novelty: 0.29561674
Score: 0.805
Data Source: STRINGDB
TCTN1
Tbio
Novelty: 0.0657704
Score: 0.79
Data Source: STRINGDB
TCTN2
Tbio
Novelty: 0.11617528
Score: 0.771
Data Source: STRINGDB
TTC21B
Tbio
Novelty: 0.02480259
Score: 0.768
Data Source: STRINGDB
TMEM237
Tdark
Novelty: 0.27005874
Score: 0.766
Data Source: STRINGDB
CC2D2A
Tbio
Novelty: 0.03684487
Score: 0.75
Data Source: STRINGDB
TMEM67
Tbio
Novelty: 0.02573267
Score: 0.744
Data Source: STRINGDB
Publication Statistics
PubMed Score  2.38

PubMed score by year
PubTator Score  3.07

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer