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Tchem
ATM
Serine-protein kinase ATM

Protein Summary
Description
Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and monospecific recognition by the B-cell antigen receptor (BCR) expressed on individual B-lymphocytes. After the introduction of DNA breaks by the RAG complex on one immunoglobulin allele, acts by mediating a repositioning of the second allele to pericentromeric heterochromatin, preventing accessibility to the RAG complex and recombination of the second allele. Also involved in signal transduction and cell cycle control. May function as ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000278616
  • ENSP00000278616
  • ENSG00000149311
  • ENST00000452508
  • ENSP00000388058

Symbol
  • AT1
  • ATA
  • ATC
  • ATD
  • ATE
  • ATDC
  • TEL1
  • TELO1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
hub protein
1
molecular function
0.99
protein domain
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4007.4   (req: < 5)
View Publications
Gene RIFs: 876   (req: <= 3)
View Gene RIFs
Antibodies: 1297   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4007.4   (req: >= 5)
Gene RIFs: 876   (req: > 3)
Antibodies: 1297   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 60
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 62
Explore Active Ligands
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (94)
Autodegradation of the E3 ubiquitin ligase COP1 (R-HSA-349425)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 47
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Autodegradation of the E3 ubiquitin ligase COP1
52 targets
R-HSA-349425
Reactome
Cell Cycle
597 targets
R-HSA-1640170
Reactome
Cell Cycle Checkpoints
272 targets
R-HSA-69620
Reactome
Cellular Senescence
164 targets
R-HSA-2559583
Reactome
Cellular response to heat stress
100 targets
R-HSA-3371556
Name
Explore in Pharos
Explore in Source
Autodegradation of the E3 ubiquitin ligase COP1
52 targets
R-HSA-349425
Cell Cycle
597 targets
R-HSA-1640170
Cell Cycle Checkpoints
272 targets
R-HSA-69620
Cellular Senescence
164 targets
R-HSA-2559583
Cellular response to heat stress
100 targets
R-HSA-3371556
Gene Ontology Terms (65)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
DNA-dependent protein kinase activity
Inferred from Direct Assay (IDA)
BHF-UCL
protein dimerization activity
Inferred from Direct Assay (IDA)
BHF-UCL
protein N-terminus binding
Inferred from Direct Assay (IDA)
UniProtKB
protein serine/threonine kinase activity
Inferred from Direct Assay (IDA)
UniProtKB
protein-containing complex binding
Inferred from Direct Assay (IDA)
BHF-UCL
1-phosphatidylinositol-3-kinase activity
Inferred from Mutant Phenotype (IMP)
UniProtKB
ATP binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
DNA binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (773)
1 – 10 of 773
BSG
Tbio
Novelty: 0.00077805
p_int: 0.999703694
p_ni: 0.000296306
Score: 0.176
Data Source: BioPlex,STRINGDB
NPY2R
Tchem
Family: GPCR
Novelty: 0.01163073
p_int: 0.999453496
p_ni: 0.000546504
Data Source: BioPlex
LPAR4
Tchem
Family: GPCR
Novelty: 0.03711071
p_int: 0.998722317
p_ni: 0.001277683
Data Source: BioPlex
OPALIN
Tdark
Novelty: 0.06813417
p_int: 0.996389559
p_ni: 0.003610441
Data Source: BioPlex
CYB5B
Tbio
Novelty: 0.11412954
p_int: 0.995539998
p_ni: 0.004460002
Data Source: BioPlex
OPRM1
Tclin
Family: GPCR
Novelty: 0.00035782
p_int: 0.991659554
p_ni: 0.008340433
p_wrong: 1.3e-8
Data Source: BioPlex
CD70
Tbio
Novelty: 0.00552433
p_int: 0.985072571
p_ni: 0.014927429
Data Source: BioPlex
EDNRB
Tclin
Family: GPCR
Novelty: 0.00055047
p_int: 0.960986668
p_ni: 0.039013332
Score: 0.194
Data Source: BioPlex,STRINGDB
CD274
Tclin
Novelty: 0.00020953
p_int: 0.933939845
p_ni: 0.066060154
p_wrong: 1e-9
Score: 0.345
Data Source: BioPlex,STRINGDB
P2RY8
Tbio
Family: GPCR
Novelty: 0.08044634
p_int: 0.897345414
p_ni: 0.102654586
Data Source: BioPlex
Publication Statistics
PubMed Score  4007.40

PubMed score by year
PubTator Score  2255.25

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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