Tdark C11orf52 Uncharacterized protein C11orf52

Protein Summary

Uniprot Accession IDs

• Q96A22

Gene Name

• C11orf52

Ensembl ID

• ENST00000278601
• ENSP00000278601
• ENSG00000149300

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.79   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 23   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.79   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 23   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (11)

Explore Interacting Targets

1 – 10 of 11

• See Interactions on String-DB

FRMD4A

Tbio

Novelty:  0.10960581

Score:  0.581

Data Source:  STRINGDB

TMEM86A

Tdark

Family:  Enzyme

Novelty:  1.07989252

Score:  0.512

Data Source:  STRINGDB

IFFO1

Tdark

Novelty:  0.38051741

Score:  0.51

Data Source:  STRINGDB

TMEM87A

Tdark

Novelty:  0.33614983

Score:  0.473

Data Source:  STRINGDB

PPEF2

Tbio

Family:  Enzyme

Novelty:  0.18717195

Score:  0.45

Data Source:  STRINGDB

DTWD1

Tdark

Novelty:  0.53044591

Score:  0.449

Data Source:  STRINGDB

BCLAF3

Tdark

Novelty:  1.67603845

Score:  0.443

Data Source:  STRINGDB

CRYGN

Tdark

Novelty:  0.29650893

Score:  0.43

Data Source:  STRINGDB

TRAF3IP3

Tbio

Novelty:  0.12180834

Score:  0.42

Data Source:  STRINGDB

TMCC3

Tdark

Novelty:  0.67741343

Score:  0.42

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (1)

PathwayCommons (1)

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5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
PathwayCommons: netpath	EGFR1	472 targets	PathwayCommons: netpath

Name	Explore in Pharos	Explore in Source
EGFR1	472 targets	PathwayCommons: netpath

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (1)

Components (1)

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Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
extracellular exosome	Inferred from High Throughput Direct Assay (HDA)	UniProtKB

Disease Associations ()

No disease associations found

GWAS Traits (9)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	2	3	3		90.6
waist circumference	EFO_0004342	1	2	2		64.2
BMI-adjusted waist-hip ratio	EFO_0007788	1	2	2		61.8
smoking status measurement	EFO_0006527	1	1	1		56.4
mean platelet volume	EFO_0004584	1	1	1		49.5

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 9

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
waist-hip ratio	EFO_0004343	3		90.6
waist circumference	EFO_0004342	2		64.2
BMI-adjusted waist-hip ratio	EFO_0007788	2		61.8
smoking status measurement	EFO_0006527	1		56.4
mean platelet volume	EFO_0004584	1		49.5

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UniProt Keyword Find Similar Targets

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Complete proteome
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

No Header	No Header
birth weight
BMI-adjusted hip circumference
BMI-adjusted waist-hip ratio
mean platelet volume
red blood cell distribution width
smoking status measurement
triglyceride measurement
waist circumference
waist-hip ratio

IDG Resources

No IDG generated resources found

Orthologs (7)

1 – 5 of 7

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	chromosome 11 C11orf52 homolog	VGNC:3179	738507
Mouse	RIKEN cDNA 2310030G06 gene	MGI:1914202	66952
Rat	hypothetical protein LOC689959	RGD:1586341	689959
Dog	chromosome 5 C11orf52 homolog	VGNC:50434	489407
Horse	chromosome 7 C11orf52 homolog	VGNC:52348	100070452

Species	Name	OMA	EggNOG	Inparanoid
Chimp	chromosome 11 C11orf52 homolog
Mouse	RIKEN cDNA 2310030G06 gene
Rat	hypothetical protein LOC689959
Dog	chromosome 5 C11orf52 homolog
Horse	chromosome 7 C11orf52 homolog

Publication Statistics

PubMed Score 0.79

PubMed score by year

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PubTator Score 0.11

PubTator score by year

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Related Publications

Text Mined References (6)

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10

0 of 0

PMID	Year	Title