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Tbio
MINDY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

Protein Summary
Description
Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. The protein encoded by this gene contains a caspase-associated recruitment domain and may function in apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000277632
  • ENSP00000277632
  • ENSG00000148481

Symbol
  • C10orf97
  • CARP
  • DERP5
  • FAM188A
  • CARP
  • DERP5
  • my042
  • MST126
  • FAM188A
  • MSTP126
  • C10orf97
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.07   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 43   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.07   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 43   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
1
1
22.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
1
22.3
Protein-Protein Interactions (54)
1 – 10 of 54
HNRNPLL
Tbio
Novelty: 0.0498467
p_int: 0.999769237
p_ni: 0.000230647
p_wrong: 1.15e-7
Score: 0.19
Data Source: BioPlex,STRINGDB
UBB
Tbio
Novelty: 0.00661254
p_int: 0.999757979
p_ni: 0.000242021
Data Source: BioPlex
KIFC1
Tchem
Novelty: 0.00982095
p_int: 0.9997408
p_ni: 0.0002592
Score: 0.211
Data Source: BioPlex,STRINGDB
CD19
Tclin
Novelty: 0.0001816
p_int: 0.999499256
p_ni: 0.000500744
Score: 0.207
Data Source: BioPlex,STRINGDB
SCAF8
Tbio
Novelty: 0.1650699
p_int: 0.99941855
p_ni: 0.000581446
p_wrong: 4e-9
Score: 0.27
Data Source: BioPlex,STRINGDB
RNF25
Tbio
Family: Enzyme
Novelty: 0.08945219
p_int: 0.998605654
p_ni: 0.001394345
p_wrong: 1e-9
Score: 0.211
Data Source: BioPlex,STRINGDB
LANCL2
Tchem
Novelty: 0.06086418
p_int: 0.996382089
p_ni: 0.00361791
p_wrong: 1e-9
Score: 0.545
Data Source: BioPlex,STRINGDB
ZNF644
Tbio
Family: TF
Novelty: 0.12816167
p_int: 0.993168794
p_ni: 0.006830549
p_wrong: 6.57e-7
Data Source: BioPlex
MPP6
Tbio
Novelty: 0.08883057
p_int: 0.98353445
p_ni: 0.01646555
Score: 0.19
Data Source: BioPlex,STRINGDB
DOK2
Tbio
Novelty: 0.02651438
p_int: 0.968557897
p_ni: 0.031442103
Score: 0.309
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  33.07

PubMed score by year
PubTator Score  1.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer