Tbio CRH Corticoliberin

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Corticoliberin

DTO Classes

Protein / Signaling / Hormone / Corticoliberin

Protein Summary

Description

Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P06850
• B3KQS4

Gene Name

• CRH

Ensembl ID

• ENST00000276571
• ENSP00000276571
• ENSG00000147571

Symbol

• CRF
• CRH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	0.94
chemical	0.89
disease	0.69
gene perturbation	0.68

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5892.11   (req: < 5)

Gene RIFs: 145   (req: <= 3)

Antibodies: 507   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5892.11   (req: >= 5)

Gene RIFs: 145   (req: > 3)

Antibodies: 507   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (42)

Reactome (11)

KEGG (4)

PathwayCommons (8)

WikiPathways (19)

Class B/2 (Secretin family receptors) (R-HSA-373080)

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Items per page:

5

1 – 5 of 11

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
Reactome	G alpha (s) signalling events	577 targets	R-HSA-418555
Reactome	GPCR downstream signalling	1152 targets	R-HSA-388396
Reactome	GPCR ligand binding	460 targets	R-HSA-500792
Reactome	Gene expression (Transcription)	1452 targets	R-HSA-74160

Name	Explore in Pharos	Explore in Source
Class B/2 (Secretin family receptors)	97 targets	R-HSA-373080
G alpha (s) signalling events	577 targets	R-HSA-418555
GPCR downstream signalling	1152 targets	R-HSA-388396
GPCR ligand binding	460 targets	R-HSA-500792
Gene expression (Transcription)	1452 targets	R-HSA-74160

Gene Ontology Terms (60)

Functions (6)

Components (5)

Processes (49)

Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
corticotropin-releasing hormone activity	Inferred from Biological aspect of Ancestor (IBA)	GO_Central
hormone activity	Traceable Author Statement (TAS)	ProtInc
neuropeptide hormone activity	Traceable Author Statement (TAS)	ProtInc
signaling receptor binding	Traceable Author Statement (TAS)	ProtInc
corticotropin-releasing hormone receptor 1 binding	Inferred from Electronic Annotation (IEA)	Ensembl
corticotropin-releasing hormone receptor 2 binding	Inferred from Electronic Annotation (IEA)	Ensembl

Protein-Protein Interactions (276)

Explore Interacting Targets

1 – 10 of 276

• See Interactions on String-DB

UBR1

Tbio

Family: Enzyme

Novelty: 0.00742688

p_int: 0.983391919

p_ni: 0.016608081

Score: 0.187

Data Source: BioPlex,STRINGDB

RRAS

Tbio

Family: Enzyme

Novelty: 0.00229703

p_int: 0.825752109

p_ni: 0.16124927

p_wrong: 0.012998621

Score: 0.319

Data Source: BioPlex,STRINGDB

CRHR2

Tbio

Family: GPCR

Novelty: 0.00324955

Score: 0.999

Data Source: Reactome,STRINGDB

CRHR1

Tclin

Family: GPCR

Novelty: 0.00121307

Score: 0.999

Data Source: Reactome,STRINGDB

POMC

Tbio

Novelty: 0.00002654

Score: 0.997

Data Source: STRINGDB

CRHBP

Tbio

Novelty: 0.00918779

Score: 0.996

Data Source: Reactome,STRINGDB

UCN

Tbio

Novelty: 0.00171727

Score: 0.993

Data Source: STRINGDB

AVP

Tbio

Novelty: 0.0001163

Score: 0.99

Data Source: STRINGDB

NPS

Tbio

Novelty: 0.00011983

Score: 0.985

Data Source: STRINGDB

MC4R

Tclin

Family: GPCR

Novelty: 0.00104053

Score: 0.979

Data Source: STRINGDB

Publication Statistics

PubMed Score  5892.11

PubMed score by year

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PubTator Score  5424.69

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQARPVLLRMGE

1-70

EYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLLLPRRSLDSPAALAERGARNA

70-140

LGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK

140-196

MRLPLLVSAGVLLVALLPCPPCRALLSRGPVPGARQAPQHPQPLDFFQPPPQSEQPQQPQARPVLLRMGEEYFLRLGNLNKSPAAPLSPASSLLAGGSGSRPSPEQATANFFRVLLQQLLLPRRSLDSPAALAERGARNALGGHQEAPERERRSEEPPISLDLTFHLLREVLEMARAEQLAQQAHSNRKLMEIIGK

Find similar targets by:

Uniprot Keyword

3D-structure
Amidation
Cleavage on pair of basic residues
Complete proteome
Direct protein sequencing
Hormone
Polymorphism
Reference proteome
Secreted
Signal