Tbio CRH Corticoliberin

Protein Summary

Description

Hormone regulating the release of corticotropin from pituitary gland (By similarity). Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity). This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P06850
• B3KQS4

Gene Name

• CRH

Ensembl ID

• ENST00000276571
• ENSP00000276571
• ENSG00000147571

Symbol

• CRF
• CRH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	1
biological term	0.94
chemical	0.89
disease	0.69
gene perturbation	0.68

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Peptide Hormone / Corticoliberin

DTO Classes

Protein / Signaling / Hormone / Corticoliberin

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6709.01   (req: < 5)

Gene RIFs: 156   (req: <= 3)

Antibodies: 507   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6709.01   (req: >= 5)

Gene RIFs: 156   (req: > 3)

Antibodies: 507   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 55

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0