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Tdark
TMEM47
Transmembrane protein 47

Protein Summary
Description
Regulates cell junction organization in epithelial cells. May play a role in the transition from adherens junction to tight junction assembly. May regulate F-actin polymerization required for tight junctional localization dynamics and affect the junctional localization of PARD6B. During podocyte differentiation may negatively regulate activity of FYN and subsequently the abundance of nephrin (By similarity). This gene encodes a member of the PMP22/EMP/claudin protein family. The encoded protein is localized to the ER and the plasma membrane. In dogs, transcripts of this gene exist at high levels in the brain. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275954
  • ENSP00000275954
  • ENSG00000147027

Symbol
  • BCMP1
  • TM4SF10
  • BCMP1
  • VAB-9
  • TM4SF10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.84
PubMedID
0.78
small molecule perturbation
0.66
gene perturbation
0.53


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.63   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 27   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.63   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:2177570
192216
Rat
RGD:1564799
501569
Dog
transmembrane protein 47
VGNC:47584
403572
Cow
transmembrane protein 47
VGNC:36090
541164
Pig
transmembrane protein 47
100157181
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
transmembrane protein 47
Cow
transmembrane protein 47
Pig
transmembrane protein 47
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BQJ4-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (5)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
LIFEdb
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (44)
1 – 10 of 44
AGTRAP
Tbio
Novelty: 0.02295361
p_int: 0.999795224
p_ni: 0.000127028
p_wrong: 0.000077747
Data Source: BioPlex
SNX8
Tbio
Novelty: 0.02652492
p_int: 0.998855511
p_ni: 0.001144442
p_wrong: 4.7e-8
Data Source: BioPlex
CLCN7
Tchem
Family: IC
Novelty: 0.00764796
p_int: 0.968688048
p_ni: 0.014606024
p_wrong: 0.016705928
Data Source: BioPlex
CD63
Tchem
Novelty: 0.00072515
p_int: 0.936343015
p_ni: 0.063656975
p_wrong: 1.1e-8
Data Source: BioPlex
ATP13A3
Tbio
Family: Transporter
Novelty: 0.13498113
p_int: 0.858529173
p_ni: 0.141452685
p_wrong: 0.000018141
Data Source: BioPlex
SLC17A5
Tbio
Family: Transporter
Novelty: 0.00678585
p_int: 0.794896293
p_ni: 0.000016936
p_wrong: 0.205086771
Data Source: BioPlex
TMEM176B
Tbio
Novelty: 0.02452255
Score: 0.692
Data Source: STRINGDB
RIMBP2
Tdark
Novelty: 0.06169893
Score: 0.685
Data Source: STRINGDB
TMEM176A
Tbio
Novelty: 0.11044555
Score: 0.67
Data Source: STRINGDB
UBE2V2
Tbio
Novelty: 0.01112479
Score: 0.658
Data Source: STRINGDB
Publication Statistics
PubMed Score  10.63

PubMed score by year
PubTator Score  3.58

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer