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Tclin
EGFR
Epidermal growth factor receptor

Protein Summary
Description
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275493
  • ENSP00000275493
  • ENSG00000146648
  • ENST00000342916
  • ENSP00000342376
  • ENST00000344576
  • ENSP00000345973
  • ENST00000420316
  • ENSP00000413843

Symbol
  • ERBB
  • ERBB1
  • HER1
  • ERBB
  • HER1
  • mENA
  • ERBB1
  • PIG61
  • NISBD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
interacting protein
1


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19716.01   (req: < 5)
Gene RIFs: 5579   (req: <= 3)
Antibodies: 8544   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 19716.01   (req: >= 5)
Gene RIFs: 5579   (req: > 3)
Antibodies: 8544   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 115
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2419
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 26