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Tclin
EGFR
Epidermal growth factor receptor

Protein Summary
Description
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses (PubMed:2790960, PubMed:10805725, PubMed:27153536). Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF (PubMed:2790960, PubMed:7679104, PubMed:8144591, PubMed:9419975, PubMed:15611079, PubMed:12297049, PubMed:27153536, PubMed:20837704). Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules (PubMed:27153536). May also activate the NF-kappa-B signaling cascade (PubMed:11116146). Also directly phosphorylates other proteins like RGS ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000275493
  • ENSP00000275493
  • ENSG00000146648
  • ENST00000342916
  • ENSP00000342376
  • ENST00000344576
  • ENSP00000345973
  • ENST00000420316
  • ENSP00000413843

Symbol
  • ERBB
  • ERBB1
  • HER1
  • ERBB
  • HER1
  • mENA
  • ERBB1
  • PIG61
  • NISBD2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
interacting protein
1


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15684.43   (req: < 5)
Gene RIFs: 4532   (req: <= 3)
Antibodies: 8544   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15684.43   (req: >= 5)
Gene RIFs: 4532   (req: > 3)
Antibodies: 8544   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 115
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1544
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 20
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.3
95.4
2
2
0
1.3
91.8
age at onset
1
2
0
1.3
72
2
1
0
1.4
66.8
lymphocyte count
1
1
1
43.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
95.4
0
1.3
91.8
age at onset
0
1.3
72
0
1.4
66.8
lymphocyte count
1
43.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epidermal growth factor receptor
VGNC:4334
463415
Macaque
epidermal growth factor receptor
613027
Mouse
MGI:95294
13649
Rat
RGD:2543
24329
Dog
epidermal growth factor receptor
VGNC:51866
404306
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epidermal growth factor receptor
Macaque
epidermal growth factor receptor
Mouse
Rat
Dog
epidermal growth factor receptor
Protein Structure (187 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00533-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 187
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (286)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 68
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Constitutive Signaling by EGFRvIII
Name
Explore in Pharos
Explore in Source
Axon guidance
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Constitutive Signaling by Aberrant PI3K in Cancer
Constitutive Signaling by EGFRvIII
Gene Ontology Terms (141)
Items per page:
10
1 – 10 of 22
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Protein-Protein Interactions (1356)
1 – 10 of 1356
PTPRK
Tbio
Family: Enzyme
Novelty: 0.03149943
p_int: 0.986353229
p_ni: 0.013646771
Score: 0.968
Data Source: BioPlex,STRINGDB
PON2
Tbio
Family: Enzyme
Novelty: 0.00414855
p_int: 0.979993732
p_ni: 0.020006268
Score: 0.205
Data Source: BioPlex,STRINGDB
DHFR2
Tbio
Family: Enzyme
Novelty: 0.02374466
p_int: 0.970297603
p_ni: 0.029702397
Data Source: BioPlex
PTCH1
Tbio
Novelty: 0.00077635
p_int: 0.969124726
p_ni: 0.030875274
Score: 0.566
Data Source: BioPlex,STRINGDB
PATE1
Tbio
Novelty: 0.0705075
p_int: 0.95782295
p_ni: 0.04217705
Data Source: BioPlex
SCGB1D4
Tdark
Novelty: 0.15597658
p_int: 0.932285955
p_ni: 0.067714045
Score: 0.272
Data Source: BioPlex,STRINGDB
DEFA1
Tbio
Novelty: 0.01027492
p_int: 0.926778686
p_ni: 0.073221314
Score: 0.219
Data Source: BioPlex,STRINGDB
ST8SIA4
Tbio
Family: Enzyme
Novelty: 0.00338436
p_int: 0.85279415
p_ni: 0.14720585
Score: 0.354
Data Source: BioPlex,STRINGDB
HTR3A
Tclin
Family: IC
Novelty: 0.00217443
p_int: 0.850971038
p_ni: 0.149028962
Score: 0.192
Data Source: BioPlex,STRINGDB
PCDHB11
Tdark
Novelty: 0.80480462
p_int: 0.846703153
p_ni: 0.153296847
Data Source: BioPlex
Publication Statistics
PubMed Score  15684.43

PubMed score by year
PubTator Score  25756.13

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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