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Tdark
PSD2
PH and SEC7 domain-containing protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274710
  • ENSP00000274710
  • ENSG00000146005

Symbol
  • EFA6C
  • EFA6C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.86
protein domain
0.73
cell line
0.61
tissue sample
0.6
cell type or tissue
0.57


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.65   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 17   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 30.65   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 17   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin and Sec7 domain containing 2
VGNC:4137
462110
Macaque
pleckstrin and Sec7 domain containing 2
694873
Mouse
MGI:1921252
74002
Rat
RGD:1311075
307500
Dog
pleckstrin and Sec7 domain containing 2
VGNC:45083
487157
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin and Sec7 domain containing 2
Macaque
pleckstrin and Sec7 domain containing 2
Mouse
Rat
Dog
pleckstrin and Sec7 domain containing 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9BQI7-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Protein-Protein Interactions (90)
1 – 10 of 90
FARP2
Tbio
Novelty: 0.09590913
p_int: 0.999428878
p_ni: 0.000571103
p_wrong: 1.9e-8
Data Source: BioPlex
FARP1
Tbio
Novelty: 0.04040696
p_int: 0.998712592
p_ni: 0.001287376
p_wrong: 3.2e-8
Data Source: BioPlex
ZBTB49
Tdark
Family: TF
Novelty: 2.32287223
p_int: 0.994795348
p_ni: 0.005202627
p_wrong: 0.000002024
Data Source: BioPlex
UHRF1
Tbio
Family: Epigenetic
Novelty: 0.00482565
p_int: 0.994756415
p_ni: 0.005243564
p_wrong: 2.1e-8
Data Source: BioPlex
DCAF16
Tdark
Novelty: 0.35666992
p_int: 0.993938825
p_ni: 0.004889921
p_wrong: 0.001171254
Data Source: BioPlex
NMT2
Tchem
Family: Enzyme
Novelty: 0.04826835
p_int: 0.989289131
p_ni: 0.010709885
p_wrong: 9.85e-7
Data Source: BioPlex
SETD2
Tchem
Family: Epigenetic
Novelty: 0.00178899
p_int: 0.986835179
p_ni: 0.013164795
p_wrong: 2.6e-8
Data Source: BioPlex
NMT1
Tchem
Family: Enzyme
Novelty: 0.00343834
p_int: 0.892342779
p_ni: 0.107657221
Data Source: BioPlex
PPM1G
Tbio
Family: Enzyme
Novelty: 0.02646519
p_int: 0.796547016
p_ni: 0.203452984
Data Source: BioPlex
TRMT11
Tbio
Family: Enzyme
Novelty: 0.11506701
p_int: 0.792556554
p_ni: 0.207290305
p_wrong: 0.000153141
Data Source: BioPlex
Publication Statistics
PubMed Score  30.65

PubMed score by year
PubTator Score  9.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer