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Tclin
GABRB2
Gamma-aminobutyric acid receptor subunit beta-2

Protein Classes
Protein Summary
Description
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel. The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 2 subunit. It is mapped to chromosome 5q34 in a cluster comprised of genes encoding alpha 1 and gamma 2 subunits of the GABA A receptor. Alternative splicing of this gene generates 2 transcript variants, differing by a 114 bp insertion. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274547
  • ENSP00000274547
  • ENSG00000145864
  • ENST00000353437
  • ENSP00000274546
  • ENST00000393959
  • ENSP00000377531
  • ENST00000520240
  • ENSP00000429320
  • ENST00000612710
  • ENSP00000480066

Symbol
  • ICEE2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
co-expressed gene
0.96
molecular function
0.88
protein domain
0.85
chemical
0.84


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.83   (req: < 5)
Gene RIFs: 51   (req: <= 3)
Antibodies: 312   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.83   (req: >= 5)
Gene RIFs: 51   (req: > 3)
Antibodies: 312   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 37
Approved Drugs (37)
1 – 10 of 37
topiramate
chemical structure image
triazolam
chemical structure image
diazepam
chemical structure image
halothane
chemical structure image
midazolam
chemical structure image
isoflurane
chemical structure image
zopiclone
chemical structure image
zolpidem
chemical structure image
desflurane
chemical structure image
sevoflurane
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
1
1
68.5
self reported educational attainment
1
1
1
45.6
multisite chronic pain
1
1
1
15.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
1
68.5
self reported educational attainment
1
45.6
multisite chronic pain
1
15.7
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (15)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Signal Transduction
Signaling by ERBB4
Gene Ontology Terms (30)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (171)
1 – 10 of 171
GABRB3
Tclin
Family: IC
Novelty: 0.00485997
p_int: 0.999999792
p_ni: 8e-9
p_wrong: 2e-7
Score: 0.916
Data Source: BioPlex,Reactome,STRINGDB
ARHGEF25
Tbio
Novelty: 0.02782136
p_int: 0.94887039
p_ni: 0.021891424
p_wrong: 0.029238186
Score: 0.523
Data Source: BioPlex,STRINGDB
GABRG2
Tclin
Family: IC
Novelty: 0.00819163
Score: 0.989
Data Source: Reactome,STRINGDB
GABRA1
Tclin
Family: IC
Novelty: 0.0094079
Score: 0.988
Data Source: Reactome,STRINGDB
GABRA5
Tclin
Family: IC
Novelty: 0.01499706
Score: 0.98
Data Source: STRINGDB
GABRA6
Tclin
Family: IC
Novelty: 0.02894664
Score: 0.976
Data Source: STRINGDB
GABRA4
Tclin
Family: IC
Novelty: 0.03089903
Score: 0.97
Data Source: STRINGDB
GABRA2
Tclin
Family: IC
Novelty: 0.00663529
Score: 0.963
Data Source: STRINGDB
GABRA3
Tclin
Family: IC
Novelty: 0.02180091
Score: 0.961
Data Source: STRINGDB
GABRG3
Tclin
Family: IC
Novelty: 0.0420649
Score: 0.94
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  51.83

PubMed score by year
PubTator Score  31.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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