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Tdark
UGT3A1
UDP-glucuronosyltransferase 3A1

Protein Summary
Description
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274278
  • ENSP00000274278
  • ENSG00000145626
  • ENST00000333811
  • ENSP00000328033
  • ENST00000625798
  • ENSP00000487376
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell line
0.68
gene perturbation
0.68
cellular component
0.54
microRNA
0.49
metabolite
0.45


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.44   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 38   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.44   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 38   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
1
1
58.1
blood metabolite measurement
1
1
1
44.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum metabolite measurement
1
58.1
blood metabolite measurement
1
44.7
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
UDP glycosyltransferase family 3 member A1
VGNC:8653
471571
Macaque
UDP glycosyltransferase family 3 member A1
700115
Mouse
MGI:2145969
223337
Rat
RGD:1564365
294793
Horse
UDP-glucuronosyltransferase 3A1-like
100067768
Species
Name
OMA
EggNOG
Inparanoid
Chimp
UDP glycosyltransferase family 3 member A1
Macaque
UDP glycosyltransferase family 3 member A1
Mouse
Rat
Horse
UDP-glucuronosyltransferase 3A1-like
Pathways (4)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Glucuronidation
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Glucuronidation
Metabolism
Phase II - Conjugation of compounds
Protein-Protein Interactions (40)
1 – 10 of 40
EXT2
Tbio
Family: Enzyme
Novelty: 0.00480574
Score: 0.72
Data Source: STRINGDB
SLCO1A2
Tchem
Family: Transporter
Novelty: 0.00248357
Score: 0.713
Data Source: STRINGDB
SLC35A2
Tbio
Family: Transporter
Novelty: 0.00072521
Score: 0.698
Data Source: STRINGDB
CWC25
Tdark
Novelty: 0.13727856
Score: 0.697
Data Source: STRINGDB
LIX1
Tbio
Novelty: 0.03028158
Score: 0.697
Data Source: STRINGDB
ACOT11
Tbio
Family: Enzyme
Novelty: 0.0400726
Score: 0.697
Data Source: STRINGDB
PGM2
Tbio
Family: Enzyme
Novelty: 0.00922421
Score: 0.697
Data Source: STRINGDB
RUBCNL
Tbio
Novelty: 0.20019585
Score: 0.697
Data Source: STRINGDB
C1orf109
Tdark
Novelty: 0.93042195
Score: 0.697
Data Source: STRINGDB
CALHM4
Tdark
Family: IC
Novelty: 2.79788039
Score: 0.697
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.44

PubMed score by year
PubTator Score  3.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer