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Tclin
NDUFS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

Protein Classes
Protein Summary
Description
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. This gene encodes a subunit of the NADH:ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. The subunit encoded by this gene is one of seven subunits in the iron-sulfur protein fraction. Mutations in this gene cause mitochondrial complex I deficiency, a disease that causes a wide variety of clinical disorders, including neonatal disease and adult-onset neurodegenerative disorders.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274137
  • ENSP00000274137
  • ENSG00000145494

Symbol
  • MC1DN9
  • CI-13kA
  • CI13KDA
  • CI-13kD-A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
transcription factor perturbation
0.88
virus perturbation
0.83
transcription factor binding site profile
0.79
cell type or tissue
0.77


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.85   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 192   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.85   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 192   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit S6
VGNC:4097
742848
Macaque
NADH:ubiquinone oxidoreductase subunit S6
709426
Mouse
MGI:107932
407785
Dog
NADH:ubiquinone oxidoreductase subunit S6
VGNC:43709
478629
Horse
NADH:ubiquinone oxidoreductase subunit S6
VGNC:20647
100071879
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase subunit S6
Macaque
NADH:ubiquinone oxidoreductase subunit S6
Mouse
Dog
NADH:ubiquinone oxidoreductase subunit S6
Horse
NADH:ubiquinone oxidoreductase subunit S6
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75380-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Protein-Protein Interactions (201)
1 – 10 of 201
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999999246
p_ni: 7.35e-7
p_wrong: 1.9e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB7
Tclin
Family: Enzyme
Novelty: 0.14580093
p_int: 0.999999133
p_ni: 8.29e-7
p_wrong: 3.8e-8
Score: 0.999
Data Source: BioPlex,STRINGDB
MT-ND5
Tclin
Family: Enzyme
Novelty: 0.00223164
p_int: 0.999984131
p_ni: 0.000015868
Score: 0.995
Data Source: BioPlex,STRINGDB
NDUFB6
Tclin
Family: Enzyme
Novelty: 0.075245
p_int: 0.999970698
p_ni: 0.000029295
p_wrong: 7e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFC2
Tclin
Family: Enzyme
Novelty: 0.08387385
p_int: 0.999947446
p_ni: 0.000052554
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS4
Tclin
Family: Enzyme
Novelty: 0.00787292
p_int: 0.999933264
p_ni: 0.000023318
p_wrong: 0.000043418
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFV2
Tclin
Family: Enzyme
Novelty: 0.02240263
p_int: 0.999931117
p_ni: 0.000068883
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB8
Tclin
Family: Enzyme
Novelty: 0.019021
p_int: 0.999929811
p_ni: 0.000070189
Score: 0.999
Data Source: BioPlex,STRINGDB
MT-ND4
Tclin
Family: Enzyme
Novelty: 0.00079935
p_int: 0.999909889
p_ni: 0.000086405
p_wrong: 0.000003707
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.999865525
p_ni: 0.000134475
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.85

PubMed score by year
PubTator Score  5.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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