Tdark ABHD14A Protein ABHD14A

Protein Summary

Description

Possible role in granule neuron development.

Uniprot Accession IDs

• Q9BUJ0
• Q6UXU8
• Q9Y3T7

Gene Name

• ABHD14A

Ensembl ID

• ENST00000273596
• ENSP00000273596
• ENSG00000248487

Symbol

• DORZ1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
histone modification site profile	0.79
transcription factor perturbation	0.68
gene perturbation	0.65
tissue	0.61

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.57   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 120   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.57   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Gene Ontology Terms (3)

Functions (1)

Components (2)

Items per page:

10

1 – 1 of 1

GO Term	Evidence	Assigned by
hydrolase activity	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (55)

Explore Interacting Targets

1 – 10 of 55

• See Interactions on String-DB

SLC39A12

Tbio

Family: Transporter

Novelty: 0.11255353

p_int: 0.984870979

p_ni: 0.015125871

p_wrong: 0.00000315

Data Source: BioPlex

IL13RA2

Tbio

Novelty: 0.04900852

p_int: 0.969797827

p_ni: 0.03020216

p_wrong: 1.3e-8

Data Source: BioPlex

CEACAM21

Tdark

Novelty: 0.98765432

p_int: 0.961374736

p_ni: 0.038625217

p_wrong: 4.7e-8

Data Source: BioPlex

SCARA3

Tbio

Novelty: 0.00826861

p_int: 0.949631709

p_ni: 0.050368291

Data Source: BioPlex

CD1E

Tbio

Novelty: 0.00231902

p_int: 0.927536271

p_ni: 0.072463729

Data Source: BioPlex

SLC39A5

Tbio

Family: Transporter

Novelty: 0.06778122

p_int: 0.926359192

p_ni: 0.073640808

Data Source: BioPlex

A4GALT

Tbio

Family: Enzyme

Novelty: 0.00253249

p_int: 0.894867248

p_ni: 0.105122593

p_wrong: 0.000010159

Score: 0.252

Data Source: BioPlex,STRINGDB

GGT7

Tbio

Family: Enzyme

Novelty: 0.0180475

p_int: 0.880854649

p_ni: 0.119111568

p_wrong: 0.000033783

Score: 0.153

Data Source: BioPlex,STRINGDB

TCTN2

Tdark

Novelty: 0.19568118

p_int: 0.87320657

p_ni: 0.126793412

p_wrong: 1.8e-8

Data Source: BioPlex

CHRNB4

Tclin

Family: IC

Novelty: 0.02388015

p_int: 0.872444896

p_ni: 0.098491678

p_wrong: 0.029063426

Data Source: BioPlex

Publication Statistics

PubMed Score  0.57

PubMed score by year

Reset Zoom

PubTator Score  0.09

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Sequence

MVGALCGCWFRLGGARPLIPLGPTVVQTSMSRSQVALLGLSLLLMLLLYVGLPGPPEQTSCLWGDPNVTV

1-70

LAGLTPGNSPIFYREVLPLNQAHRVEVVLLHGKAFNSHTWEQLGTLQLLSQRGYRAVALDLPGFGNSAPS

70-140

KEASTEAGRAALLERALRDLEVQNAVLVSPSLSGHYALPFLMRGHHQLHGFVPIAPTSTQNYTQEQFWAV

140-210

KTPTLILYGELDHILARESLRQLRHLPNHSVVKLRNAGHACYLHKPQDFHLVLLAFLDHLP

210-271

MVGALCGCWFRLGGARPLIPLGPTVVQTSMSRSQVALLGLSLLLMLLLYVGLPGPPEQTSCLWGDPNVTVLAGLTPGNSPIFYREVLPLNQAHRVEVVLLHGKAFNSHTWEQLGTLQLLSQRGYRAVALDLPGFGNSAPSKEASTEAGRAALLERALRDLEVQNAVLVSPSLSGHYALPFLMRGHHQLHGFVPIAPTSTQNYTQEQFWAVKTPTLILYGELDHILARESLRQLRHLPNHSVVKLRNAGHACYLHKPQDFHLVLLAFLDHLP

Find similar targets by:

Uniprot Keyword

Complete proteome
Cytoplasm
Glycoprotein
Hydrolase
Membrane
Polymorphism
Reference proteome
Signal-anchor
Transmembrane
Transmembrane helix