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Tbio
AMT
Aminomethyltransferase, mitochondrial

Protein Summary
Description
The glycine cleavage system catalyzes the degradation of glycine. This gene encodes one of four critical components of the glycine cleavage system. Mutations in this gene have been associated with glycine encephalopathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273588
  • ENSP00000273588
  • ENSG00000145020
  • ENST00000395338
  • ENSP00000378747
  • ENST00000458307
  • ENSP00000415619
  • ENST00000636522
  • ENSP00000489758

Symbol
  • GCST
  • GCE
  • NKH
  • GCST
  • GCVT
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.87
protein domain
0.85
cell type or tissue
0.65
transcription factor
0.63
tissue sample
0.59


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.53   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 153   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.53   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 153   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
aminomethyltransferase
VGNC:1732
461012
Macaque
aminomethyltransferase
706515
Mouse
MGI:3646700
434437
Rat
RGD:1359408
306586
Dog
aminomethyltransferase
VGNC:54572
484770
Species
Name
OMA
EggNOG
Inparanoid
Chimp
aminomethyltransferase
Macaque
aminomethyltransferase
Mouse
Rat
Dog
aminomethyltransferase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P48728-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
Glycine degradation (R-HSA-6783984)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycine degradation
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Glycine degradation
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (87)
1 – 10 of 87
GLDC
Tbio
Family: Enzyme
Novelty: 0.00900467
Score: 0.999
Data Source: STRINGDB
GCSH
Tbio
Novelty: 0.02101972
Score: 0.999
Data Source: Reactome,STRINGDB
SHMT2
Tbio
Family: Enzyme
Novelty: 0.00234505
Score: 0.989
Data Source: STRINGDB
DLD
Tbio
Family: Enzyme
Novelty: 0.00214298
Score: 0.989
Data Source: STRINGDB
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00200739
Score: 0.988
Data Source: STRINGDB
MTHFD2
Tchem
Family: Enzyme
Novelty: 0.01776594
Score: 0.979
Data Source: STRINGDB
MTHFD2L
Tdark
Family: Enzyme
Novelty: 0.18530504
Score: 0.976
Data Source: STRINGDB
MTHFD1
Tbio
Family: Enzyme
Novelty: 0.0071938
Score: 0.969
Data Source: STRINGDB
MTHFD1L
Tbio
Family: Enzyme
Novelty: 0.01548353
Score: 0.965
Data Source: STRINGDB
ATIC
Tchem
Novelty: 0.00466845
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  120.53

PubMed score by year
PubTator Score  67.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer