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Tbio
LRIG1
Leucine-rich repeats and immunoglobulin-like domains protein 1

Protein Classes
Protein Summary
Description
Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273261
  • ENSP00000273261
  • ENSG00000144749
  • ENST00000383703
  • ENSP00000373208
  • ENST00000631853
  • ENSP00000488729
  • ENSG00000282243
  • ENST00000633161
  • ENSP00000488182

Symbol
  • LIG1
  • LIG1
  • LIG-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.99
PubMedID
0.91
kinase perturbation
0.88
transcription factor binding site profile
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.56   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.56   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
2
2
80.4
2
2
0
1.1
64.8
heel bone mineral density
1
1
1
48.9
1
1
0
1.1
34.2
1
1
0
1.1
34.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
2
80.4
0
1.1
64.8
heel bone mineral density
1
48.9
0
1.1
34.2
0
1.1
34.2
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeats and immunoglobulin like domains 1
VGNC:8839
460490
Macaque
leucine rich repeats and immunoglobulin like domains 1
700033
Mouse
MGI:107935
16206
Rat
RGD:1306788
312574
Dog
leucine rich repeats and immunoglobulin like domains 1
VGNC:42767
484698
Species
Name
OMA
EggNOG
Inparanoid
Chimp
leucine rich repeats and immunoglobulin like domains 1
Macaque
leucine rich repeats and immunoglobulin like domains 1
Mouse
Rat
Dog
leucine rich repeats and immunoglobulin like domains 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q96JA1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (37)
Negative regulation of MET activity (R-HSA-6807004)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Negative regulation of MET activity
Reactome
Signal Transduction
Reactome
Signaling by EGFR
Reactome
Signaling by MET
Reactome
Signaling by Receptor Tyrosine Kinases
Name
Explore in Pharos
Explore in Source
Negative regulation of MET activity
Signal Transduction
Signaling by EGFR
Signaling by MET
Signaling by Receptor Tyrosine Kinases
Gene Ontology Terms (8)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (101)
1 – 10 of 101
LRIG3
Tbio
Novelty: 0.04502029
p_int: 0.999983983
p_ni: 0.000016016
p_wrong: 1e-9
Score: 0.736
Data Source: BioPlex,STRINGDB
LRRC40
Tdark
Novelty: 2.43377466
p_int: 0.999325143
p_ni: 0.00067432
p_wrong: 5.37e-7
Score: 0.325
Data Source: BioPlex,STRINGDB
RAB4A
Tbio
Family: Enzyme
Novelty: 0.00423197
p_int: 0.997087111
p_ni: 0.002912887
p_wrong: 2e-9
Score: 0.337
Data Source: BioPlex,STRINGDB
CNPY4
Tdark
Novelty: 0.59578334
p_int: 0.99503589
p_ni: 0.000706096
p_wrong: 0.004258014
Score: 0.363
Data Source: BioPlex,STRINGDB
CNPY3
Tbio
Novelty: 0.11473132
p_int: 0.993427245
p_ni: 0.006572755
Score: 0.622
Data Source: BioPlex,STRINGDB
CANT1
Tbio
Family: Enzyme
Novelty: 0.02640333
p_int: 0.953513127
p_ni: 0.046486873
Score: 0.209
Data Source: BioPlex,STRINGDB
SCRIB
Tbio
Novelty: 0.01099525
p_int: 0.947102558
p_ni: 0.052897442
Score: 0.247
Data Source: BioPlex,STRINGDB
MTFR1L
Tdark
Novelty: 3.23781609
p_int: 0.936095178
p_ni: 0.062590665
p_wrong: 0.001314157
Score: 0.179
Data Source: BioPlex,STRINGDB
LRIG2
Tbio
Novelty: 0.04415271
p_int: 0.928620365
p_ni: 0.071379635
Score: 0.838
Data Source: BioPlex,STRINGDB
RLN1
Tbio
Novelty: 0.03992636
p_int: 0.922540983
p_ni: 0.077459017
Data Source: BioPlex
Publication Statistics
PubMed Score  125.56

PubMed score by year
PubTator Score  84.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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