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Tbio
CTDSPL
CTD small phosphatase-like protein

Protein Summary
Description
Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273179
  • ENSP00000273179
  • ENSG00000144677
  • ENST00000443503
  • ENSP00000398288

Symbol
  • C3orf8
  • NIF1
  • NIFL
  • SCP3
  • YA22
  • PSR1
  • SCP3
  • HYA22
  • RBSP3
  • C3orf8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.95
disease perturbation
0.93
virus perturbation
0.92
histone modification site profile
0.8
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.32   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.32   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
1
2
79.7
hemoglobin measurement
2
1
2
79.6
red blood cell density measurement
1
1
1
79
monocyte count
2
2
2
70.4
lymphocyte count
2
2
2
60.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
79.7
hemoglobin measurement
2
79.6
red blood cell density measurement
1
79
monocyte count
2
70.4
lymphocyte count
2
60.6
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (2)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: pid
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
PathwayCommons: pid
BMP receptor signaling
Name
Explore in Pharos
Explore in Source
Regulation of cytoplasmic and nuclear SMAD2/3 signaling
BMP receptor signaling
Protein-Protein Interactions (60)
1 – 10 of 60
CDCA3
Tbio
Novelty: 0.05136899
p_int: 0.999999731
p_ni: 2.69e-7
Score: 0.862
Data Source: BioPlex,STRINGDB
CTDSP1
Tbio
Family: Enzyme
Novelty: 0.0231786
p_int: 0.999968843
p_ni: 5.5e-8
p_wrong: 0.000031102
Score: 0.867
Data Source: BioPlex,STRINGDB
MBP
Tbio
Novelty: 0.00016333
p_int: 0.999772849
p_ni: 0.000227111
p_wrong: 3.9e-8
Score: 0.933
Data Source: BioPlex,STRINGDB
SMAD2
Tbio
Family: TF
Novelty: 0.00040166
Score: 0.933
Data Source: STRINGDB
SMAD1
Tbio
Family: TF
Novelty: 0.02348173
Score: 0.932
Data Source: STRINGDB
SMAD3
Tbio
Family: TF
Novelty: 0.00048058
Score: 0.905
Data Source: STRINGDB
REST
Tbio
Family: TF
Novelty: 0.00260619
Score: 0.719
Data Source: STRINGDB
ITGA9
Tbio
Novelty: 0.01488635
Score: 0.717
Data Source: STRINGDB
S100A9
Tbio
Novelty: 0.00185141
Score: 0.709
Data Source: STRINGDB
S100A8
Tbio
Novelty: 0.00107914
Score: 0.671
Data Source: STRINGDB
Publication Statistics
PubMed Score  211.32

PubMed score by year
PubTator Score  26.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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