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Tbio
SLC25A38
Mitochondrial glycine transporter

Protein Summary
Description
Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix. Required during erythropoiesis. This gene is a member of the mitochondrial carrier family. The encoded protein is required during erythropoiesis and is important for the biosynthesis of heme. Mutations in this gene are the cause of autosomal congenital sideroblastic anemia (anemia, sideroblastic, 2, pyridoxine-refractory). A related pseudogene is found on chromosome 1. [provided by RefSeq, Aug 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000273158
  • ENSP00000273158
  • ENSG00000144659
  • ENST00000650617
  • ENSP00000497532

Symbol
  • SIDBA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
virus perturbation
0.83
cell type or tissue
0.8
transcription factor binding site profile
0.71
kinase perturbation
0.66


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.86   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.86   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 38
VGNC:8003
460283
Macaque
solute carrier family 25 member 38
693614
Mouse
MGI:2384782
208638
Rat
RGD:1311914
301067
Dog
solute carrier family 25 member 38
VGNC:46311
477028
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 25 member 38
Macaque
solute carrier family 25 member 38
Mouse
Rat
Dog
solute carrier family 25 member 38
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q96DW6-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (6)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (44)
1 – 10 of 44
GLRX5
Tbio
Novelty: 0.01166161
Score: 0.91
Data Source: STRINGDB
ALAS2
Tbio
Family: Enzyme
Novelty: 0.00491418
Score: 0.829
Data Source: STRINGDB
ABCB7
Tbio
Family: Transporter
Novelty: 0.00985796
Score: 0.79
Data Source: STRINGDB
FECH
Tbio
Family: Enzyme
Novelty: 0.00282289
Score: 0.788
Data Source: STRINGDB
PPOX
Tchem
Family: Enzyme
Novelty: 0.00652809
Score: 0.775
Data Source: STRINGDB
UROS
Tbio
Family: Enzyme
Novelty: 0.00938683
Score: 0.724
Data Source: STRINGDB
CCDC105
Tdark
Novelty: 9.07417322
Score: 0.709
Data Source: STRINGDB
ALAS1
Tclin
Family: Enzyme
Novelty: 0.00965779
Score: 0.708
Data Source: STRINGDB
UROD
Tbio
Family: Enzyme
Novelty: 0.00337791
Score: 0.702
Data Source: STRINGDB
PUS1
Tbio
Family: Enzyme
Novelty: 0.01923618
Score: 0.692
Data Source: STRINGDB
Publication Statistics
PubMed Score  18.86

PubMed score by year
PubTator Score  16.97

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer