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Tbio
RPS27A
Ubiquitin-40S ribosomal protein S27a

Protein Summary
Description
Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription fac ...more
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
virus perturbation
0.99
disease perturbation
0.95
transcription factor binding site profile
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.04   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 82.04   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 53
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (36)
1 – 5 of 36
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (353)
ABC transporter disorders (R-HSA-5619084)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 350
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABC transporter disorders
Reactome
ABC-family proteins mediated transport
Reactome
APC-Cdc20 mediated degradation of Nek2A
Reactome
APC/C-mediated degradation of cell cycle proteins
Reactome
APC/C:Cdc20 mediated degradation of Cyclin B
Name
Explore in Pharos
Explore in Source
ABC transporter disorders
ABC-family proteins mediated transport
APC-Cdc20 mediated degradation of Nek2A
APC/C-mediated degradation of cell cycle proteins
APC/C:Cdc20 mediated degradation of Cyclin B
Gene Ontology Terms (70)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (1561)
1 – 10 of 1561
UBAC1
Tbio
Novelty: 0.00195339
p_int: 0.999999624
p_ni: 3.76e-7
Score: 0.908
Data Source: BioPlex,STRINGDB
FAM78B
Tdark
Novelty: 1.2145749
p_int: 0.999994235
p_ni: 0.000005765
Score: 0.167
Data Source: BioPlex,STRINGDB
FARP2
Tbio
Novelty: 0.19204615
p_int: 0.999981987
p_ni: 0.000018013
Data Source: BioPlex
ZNF274
Tbio
Family: TF
Novelty: 0.03182578
p_int: 0.999979214
p_ni: 0.000020786
Score: 0.22
Data Source: BioPlex,STRINGDB
CCDC89
Tdark
Novelty: 0.49275362
p_int: 0.99996969
p_ni: 0.00003031
Data Source: BioPlex
ZNF408
Tbio
Family: TF
Novelty: 0.17075484
p_int: 0.999865258
p_ni: 0.000134742
Score: 0.2
Data Source: BioPlex,STRINGDB
ZNF263
Tdark
Family: TF
Novelty: 0.23363756
p_int: 0.999762967
p_ni: 0.000237032
p_wrong: 1e-9
Score: 0.2
Data Source: BioPlex,STRINGDB
THAP7
Tbio
Family: TF
Novelty: 0.50139276
p_int: 0.999729274
p_ni: 0.000270726
Data Source: BioPlex
ZNF133
Tbio
Family: TF
Novelty: 0.17529215
p_int: 0.999632403
p_ni: 0.000367597
Score: 0.212
Data Source: BioPlex,STRINGDB
MAK16
Tdark
Novelty: 0.07623888
p_int: 0.999468191
p_ni: 0.000531809
Score: 0.162
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  82.04

PubMed score by year
PubTator Score  22.22

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLV
1-70
LRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHY
70-140
CGKCCLTYCFNKPEDK
140-156
MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGGAKKRKKKSYTTPKKNKHKRKKVKLAVLKYYKVDENGKISRLRRECPSDECGAGVFMASHFDRHYCGKCCLTYCFNKPEDK