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Tdark
PLEKHA6
Pleckstrin homology domain-containing family A member 6

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IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.3   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.3   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
2
2
65.5
hematocrit
2
2
2
65.3
platelet count
1
2
2
57
monocyte count
1
1
1
36.9
lymphocyte count
1
1
1
36.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet crit
2
65.5
hematocrit
2
65.3
platelet count
2
57
monocyte count
1
36.9
lymphocyte count
1
36.9
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing A6
VGNC:6944
457656
Macaque
pleckstrin homology domain containing A6
702210
Mouse
MGI:2388662
240753
Dog
pleckstrin homology domain containing A6
VGNC:44670
478936
Horse
pleckstrin homology domain containing A6
VGNC:21561
100050048
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology domain containing A6
Macaque
pleckstrin homology domain containing A6
Mouse
Dog
pleckstrin homology domain containing A6
Horse
pleckstrin homology domain containing A6
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2H5-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PI Metabolism
Reactome
Phospholipid metabolism
Reactome
Synthesis of PIPs at the plasma membrane
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of lipids
PI Metabolism
Phospholipid metabolism
Synthesis of PIPs at the plasma membrane
Protein-Protein Interactions (44)
1 – 10 of 44
MYBPHL
Tdark
Novelty: 0.31786873
p_int: 0.76998545
p_ni: 0.000062456
p_wrong: 0.229952094
Score: 0.761
Data Source: BioPlex,STRINGDB
GOLT1A
Tdark
Novelty: 0.28174511
Score: 0.878
Data Source: STRINGDB
ETNK2
Tbio
Family: Kinase
Novelty: 0.13225627
Score: 0.731
Data Source: STRINGDB
PPP1R15B
Tbio
Family: Enzyme
Novelty: 0.0244819
Score: 0.73
Data Source: STRINGDB
KCNC4
Tclin
Family: IC
Novelty: 0.01215128
Score: 0.726
Data Source: STRINGDB
PIH1D1
Tbio
Novelty: 0.10737369
Score: 0.716
Data Source: STRINGDB
ALDH16A1
Tdark
Family: Enzyme
Novelty: 0.21880567
Score: 0.708
Data Source: STRINGDB
PIK3C2B
Tchem
Family: Kinase
Novelty: 0.02410654
Score: 0.658
Data Source: STRINGDB
PPFIA4
Tdark
Novelty: 0.34141709
Score: 0.633
Data Source: STRINGDB
GOLT1B
Tbio
Novelty: 0.10426627
Score: 0.625
Data Source: STRINGDB
Publication Statistics
PubMed Score  4.30

PubMed score by year
PubTator Score  1.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer