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Tclin
REN
Renin

Protein Summary
Description
Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release,vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000272190
  • ENSP00000272190
  • ENSG00000143839

Symbol
  • HNFJ2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
biological term
0.93
drug
0.79
disease
0.77
biological process
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38579.83   (req: < 5)
Gene RIFs: 169   (req: <= 3)
Antibodies: 702   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38579.83   (req: >= 5)
Gene RIFs: 169   (req: > 3)
Antibodies: 702   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2394
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
captopril
chemical structure image
aliskiren
chemical structure image
remikiren
chemical structure image
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
2
2
90.9
renin measurement
1
2
2
86.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
90.9
renin measurement
2
86.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
renin
VGNC:6977
469651
Macaque
renin
574299
Mouse
MGI:97898
19701
Rat
RGD:3554
24715
Dog
renin
VGNC:45474
403838
Species
Name
OMA
EggNOG
Inparanoid
Chimp
renin
Macaque
renin
Mouse
Rat
Dog
renin
Protein Structure (87 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P00797-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 87
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (28)
Metabolism of Angiotensinogen to Angiotensins (R-HSA-2022377)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of Angiotensinogen to Angiotensins
Reactome
Metabolism of proteins
Reactome
Peptide hormone metabolism
Name
Explore in Pharos
Explore in Source
Metabolism of Angiotensinogen to Angiotensins
Metabolism of proteins
Peptide hormone metabolism
Protein-Protein Interactions (260)
1 – 10 of 260
TMEM184B
Tdark
Novelty: 0.35340207
p_int: 0.999999252
p_ni: 7.48e-7
Score: 0.199
Data Source: BioPlex,STRINGDB
BMT2
Tbio
Family: Enzyme
Novelty: 0.05916379
p_int: 0.995473012
p_ni: 0.004036101
p_wrong: 0.000490887
Score: 0.204
Data Source: BioPlex,STRINGDB
AGT
Tbio
Novelty: 0.00049613
Score: 0.999
Data Source: Reactome,STRINGDB
ATP6AP2
Tbio
Novelty: 0.00357665
Score: 0.998
Data Source: Reactome,STRINGDB
ACE
Tclin
Family: Enzyme
Novelty: 0.00001993
Score: 0.959
Data Source: STRINGDB
AGTR1
Tclin
Family: GPCR
Novelty: 0.00033439
Score: 0.955
Data Source: STRINGDB
ACE2
Tchem
Family: Enzyme
Novelty: 0.00028408
Score: 0.95
Data Source: STRINGDB
AGTR2
Tchem
Family: GPCR
Novelty: 0.00064774
Score: 0.936
Data Source: STRINGDB
KNG1
Tchem
Novelty: 0.00007684
Score: 0.904
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.903
Data Source: STRINGDB
Publication Statistics
PubMed Score  38579.83

PubMed score by year
PubTator Score  20228.75

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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