You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
POGZ
Pogo transposable element with ZNF domain

Protein Summary
Description
Plays a role in mitotic cell cycle progression and is involved in kinetochore assembly and mitotic sister chromatid cohesion. Probably through its association with CBX5 plays a role in mitotic chromosome segregation by regulating aurora kinase B/AURKB activation and AURKB and CBX5 dissociation from chromosome arms. The protein encoded by this gene appears to be a zinc finger protein containing a transposase domain at the C-terminus. This protein was found to interact with the transcription factor SP1 in a yeast two-hybrid system. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271715
  • ENSP00000271715
  • ENSG00000143442
  • ENST00000368863
  • ENSP00000357856
  • ENST00000392723
  • ENSP00000376484
  • ENST00000409503
  • ENSP00000386836
  • ENST00000491586
  • ENSP00000418408
  • ENST00000531094
  • ENSP00000431259

Symbol
  • KIAA0461
  • SUHW5
  • ZNF280E
  • ZNF635
  • MRD37
  • WHSUS
  • ZNF635
  • ZNF280E
  • ZNF635m
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.85
kinase perturbation
0.84
microRNA
0.84
interacting protein
0.83
co-expressed gene
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.57   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 134   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 10.57   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 134   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (91)
1 – 10 of 91
HDGFL2
Tbio
Family: Epigenetic
Novelty: 0.12835229
p_int: 0.999999936
p_ni: 9e-9
p_wrong: 5.7e-8
Score: 0.844
Data Source: BioPlex,STRINGDB
ZNF428
Tdark
p_int: 0.999999804
p_ni: 1.29e-7
p_wrong: 6.7e-8
Score: 0.188
Data Source: BioPlex,STRINGDB
ZNF576
Tdark
Family: TF
p_int: 0.999999726
p_ni: 2.74e-7
Score: 0.194
Data Source: BioPlex,STRINGDB
ANKRD36B
Tdark
Novelty: 10
p_int: 0.999996627
p_ni: 0.000003373
Data Source: BioPlex
TNNC2
Tbio
Novelty: 0.11856592
p_int: 0.99997817
p_ni: 0.00002183
Data Source: BioPlex
LCOR
Tbio
Family: TF
Novelty: 0.02701833
p_int: 0.999466602
p_ni: 0.000533341
p_wrong: 5.8e-8
Data Source: BioPlex
DAXX
Tbio
Novelty: 0.00430069
p_int: 0.998806853
p_ni: 0.001193144
p_wrong: 3e-9
Score: 0.16
Data Source: BioPlex,STRINGDB
ZNF653
Tbio
Family: TF
Novelty: 2
p_int: 0.993430958
p_ni: 0.006569027
p_wrong: 1.6e-8
Data Source: BioPlex
CD4
Tclin
Novelty: 0.00001541
p_int: 0.992524011
p_ni: 0.007475889
p_wrong: 9.9e-8
Score: 0.187
Data Source: BioPlex,STRINGDB
TMEM171
Tdark
Novelty: 5.91917098
p_int: 0.989440886
p_ni: 0.010559113
Score: 0.207
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  10.57

PubMed score by year
PubTator Score  8.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer